Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1110731..1111233 Replicon chromosome
Accession NZ_CP027362
Organism Escherichia coli strain 95-3192

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag C6P51_RS06480 Protein ID WP_000767829.1
Coordinates 1110731..1110985 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag C6P51_RS06485 Protein ID WP_096136241.1
Coordinates 1110982..1111233 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6P51_RS06450 1105746..1105973 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
C6P51_RS06455 1105987..1107045 - 1059 WP_000492332.1 transport protein YeeE -
C6P51_RS06460 1107224..1108582 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
C6P51_RS06465 1108572..1108634 - 63 WP_010723108.1 membrane protein YoeI -
C6P51_RS06470 1108849..1109778 - 930 WP_000803351.1 LysR family transcriptional regulator -
C6P51_RS06475 1109824..1110648 - 825 WP_000754755.1 SDR family oxidoreductase -
C6P51_RS06480 1110731..1110985 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
C6P51_RS06485 1110982..1111233 - 252 WP_096136241.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C6P51_RS06490 1111517..1111567 + 51 WP_001364200.1 his operon leader peptide -
C6P51_RS06500 1111713..1112612 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
C6P51_RS06505 1112618..1113922 + 1305 WP_001400693.1 histidinol dehydrogenase -
C6P51_RS06510 1113919..1114989 + 1071 WP_001099213.1 histidinol-phosphate transaminase -
C6P51_RS06515 1114989..1116056 + 1068 WP_000080083.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T98325 WP_000767829.1 NZ_CP027362:c1110985-1110731 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T98325 NZ_CP027362:c1110985-1110731 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9323.58 Da        Isoelectric Point: 4.7954

>AT98325 WP_096136241.1 NZ_CP027362:c1111233-1110982 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANSRRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT98325 NZ_CP027362:c1111233-1110982 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACTCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References