Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 3986539..3986910 | Replicon | chromosome |
| Accession | NZ_CP027361 | ||
| Organism | Escherichia coli strain 2014C-4639 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A0D6ZRD3 |
| Locus tag | RR62_RS20130 | Protein ID | WP_001443846.1 |
| Coordinates | 3986761..3986910 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 3986539..3986717 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RR62_RS20105 (3982494) | 3982494..3983867 | + | 1374 | WP_000123745.1 | ATP-dependent RNA helicase DbpA | - |
| RR62_RS20110 (3983996) | 3983996..3984931 | - | 936 | WP_001157407.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| RR62_RS20115 (3984983) | 3984983..3986218 | - | 1236 | WP_000040851.1 | site-specific integrase | - |
| RR62_RS20120 (3986220) | 3986220..3986435 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (3986539) | 3986539..3986717 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (3986539) | 3986539..3986717 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (3986539) | 3986539..3986717 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (3986539) | 3986539..3986717 | + | 179 | NuclAT_0 | - | Antitoxin |
| RR62_RS20125 (3986535) | 3986535..3986723 | - | 189 | WP_001302840.1 | DUF1187 family protein | - |
| RR62_RS20130 (3986761) | 3986761..3986910 | - | 150 | WP_001443846.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| RR62_RS20135 (3986966) | 3986966..3987775 | - | 810 | WP_000166313.1 | recombination protein RecT | - |
| RR62_RS20140 (3987768) | 3987768..3990368 | - | 2601 | WP_000105151.1 | exodeoxyribonuclease VIII | - |
| RR62_RS20145 (3990470) | 3990470..3990745 | - | 276 | WP_000632297.1 | protein RacC | - |
| RR62_RS20150 (3990820) | 3990820..3990990 | - | 171 | WP_001352098.1 | YdaE family protein | - |
| RR62_RS20155 (3990990) | 3990990..3991211 | - | 222 | WP_000560223.1 | killing protein KilR | - |
| RR62_RS20160 (3991632) | 3991632..3991784 | - | 153 | WP_001427316.1 | DUF1391 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3984983..4029547 | 44564 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5383.12 Da Isoelectric Point: 8.3398
>T98301 WP_001443846.1 NZ_CP027361:c3986910-3986761 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
Download Length: 150 bp
>T98301 NZ_CP027361:c3986910-3986761 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
Antitoxin
Download Length: 179 bp
>AT98301 NZ_CP027361:3986539-3986717 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
