Detailed information of TA system TA098292

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 2122044..2122456
• Replicon: chromosome
• Accession: NZ_CP027361
• Organism: Escherichia coli strain 2014C-4639

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A0F3WCK2
• Locus tag: RR62_RS10535
• Protein ID: WP_000132621.1
• Coordinates: 2122044..2122385 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	2122380..2122456 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RR62_RS10520 (2118054)	2118054..2119466	-	1413	WP_000199352.1	PLP-dependent aminotransferase family protein	-
RR62_RS10525 (2119643)	2119643..2119807	+	165	WP_000394276.1	DUF1127 domain-containing protein	-
RR62_RS27195 (2119904)	2119904..2120786	+	883	Protein_1998	DUF262 domain-containing protein	-
RR62_RS27200 (2120834)	2120834..2121997	+	1164	WP_071531326.1	DUF1524 domain-containing protein	-
RR62_RS10535 (2122044)	2122044..2122385	-	342	WP_000132621.1	endoribonuclease SymE	Toxin
- (2122380)	2122380..2122456	+	77	NuclAT_28	-	Antitoxin
- (2122380)	2122380..2122456	+	77	NuclAT_28	-	Antitoxin
- (2122380)	2122380..2122456	+	77	NuclAT_28	-	Antitoxin
- (2122380)	2122380..2122456	+	77	NuclAT_28	-	Antitoxin
- (2122380)	2122380..2122456	+	77	NuclAT_29	-	Antitoxin
- (2122380)	2122380..2122456	+	77	NuclAT_29	-	Antitoxin
- (2122380)	2122380..2122456	+	77	NuclAT_29	-	Antitoxin
- (2122380)	2122380..2122456	+	77	NuclAT_29	-	Antitoxin
RR62_RS10540 (2122606)	2122606..2124375	-	1770	WP_000110079.1	restriction endonuclease subunit S	-
RR62_RS10545 (2124375)	2124375..2125844	-	1470	WP_001341289.1	N-6 DNA methylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12342.12 Da
• Isoelectric Point: 7.8218

>T98292 WP_000132621.1 NZ_CP027361:c2122385-2122044 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPTAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Nucleotide

• Length: 342 bp

>T98292 NZ_CP027361:c2122385-2122044 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCACCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTAC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT98292 NZ_CP027361:2122380-2122456 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0F3WCK2

Antitoxin