Detailed information of TA system TA098279

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 89701..89971
• Replicon: plasmid unnamed2
• Accession: NZ_CP027357
• Organism: Escherichia coli strain 2013C-4991

Toxin (Protein)

• Gene name: hok
• Uniprot ID: P11895
• Locus tag: C6P55_RS29805
• Protein ID: WP_001312861.1
• Coordinates: 89813..89971 (+)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	89701..89764 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6P55_RS29760	84757..85023	+	267	WP_072254135.1	hypothetical protein	-
C6P55_RS29780	85496..86023	+	528	WP_000290793.1	single-stranded DNA-binding protein	-
C6P55_RS29785	86079..86312	+	234	WP_000006004.1	DUF905 domain-containing protein	-
C6P55_RS29790	86371..88328	+	1958	Protein_90	ParB/RepB/Spo0J family partition protein	-
C6P55_RS29795	88383..88817	+	435	WP_000845895.1	conjugation system SOS inhibitor PsiB	-
C6P55_RS29800	88814..89533	+	720	WP_001276228.1	plasmid SOS inhibition protein A	-
C6P55_RS31115	89545..89733	-	189	WP_001299721.1	hypothetical protein	-
-	89545..89769	+	225	NuclAT_0	-	-
-	89545..89769	+	225	NuclAT_0	-	-
-	89545..89769	+	225	NuclAT_0	-	-
-	89545..89769	+	225	NuclAT_0	-	-
-	89701..89764	-	64	-	-	Antitoxin
C6P55_RS29805	89813..89971	+	159	WP_001312861.1	type I toxin-antitoxin system Hok family toxin	Toxin
C6P55_RS29825	90892..91179	+	288	WP_106912715.1	hypothetical protein	-
C6P55_RS29830	91299..92119	+	821	Protein_96	DUF932 domain-containing protein	-
C6P55_RS29835	92415..93017	-	603	WP_000243709.1	transglycosylase SLT domain-containing protein	-
C6P55_RS29840	93338..93721	+	384	WP_001151524.1	relaxosome protein TraM	-
C6P55_RS29845	93908..94597	+	690	WP_000283385.1	conjugal transfer transcriptional regulator TraJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	tet(A) / sitABCD	iroB / iroC / iroD / iroE / iroN / iroN	1..131463	131463

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6082.32 Da
• Isoelectric Point: 9.2584

>T98279 WP_001312861.1 NZ_CP027357:89813-89971 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 159 bp

>T98279 NZ_CP027357:89813-89971 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Nucleotide

• Length: 64 bp

>AT98279 NZ_CP027357:c89764-89701 [Escherichia coli]
GACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCTT

Structures

Toxin

• AlphaFold DB: P11895

Antitoxin