Detailed information of TA system TA098243

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4380010..4380422
• Replicon: chromosome
• Accession: NZ_CP027352
• Organism: Escherichia coli strain 2012C-4606

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A0F3WCK2
• Locus tag: AYN42_RS24040
• Protein ID: WP_000132621.1
• Coordinates: 4380010..4380351 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4380346..4380422 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYN42_RS24025	4376020..4377432	-	1413	WP_000199352.1	PLP-dependent aminotransferase family protein	-
AYN42_RS24030	4377609..4377773	+	165	WP_000394276.1	DUF1127 domain-containing protein	-
AYN42_RS24035	4377870..4379963	+	2094	WP_000648228.1	DUF262 domain-containing protein	-
AYN42_RS24040	4380010..4380351	-	342	WP_000132621.1	endoribonuclease SymE	Toxin
-	4380346..4380422	+	77	NuclAT_28	-	Antitoxin
-	4380346..4380422	+	77	NuclAT_28	-	Antitoxin
-	4380346..4380422	+	77	NuclAT_28	-	Antitoxin
-	4380346..4380422	+	77	NuclAT_28	-	Antitoxin
-	4380346..4380422	+	77	NuclAT_29	-	Antitoxin
-	4380346..4380422	+	77	NuclAT_29	-	Antitoxin
-	4380346..4380422	+	77	NuclAT_29	-	Antitoxin
-	4380346..4380422	+	77	NuclAT_29	-	Antitoxin
AYN42_RS24045	4380572..4382341	-	1770	WP_000110079.1	restriction endonuclease subunit S	-
AYN42_RS24050	4382341..4383810	-	1470	WP_001341289.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12342.12 Da
• Isoelectric Point: 7.8218

>T98243 WP_000132621.1 NZ_CP027352:c4380351-4380010 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPTAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Nucleotide

• Length: 342 bp

>T98243 NZ_CP027352:c4380351-4380010 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCACCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTAC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT98243 NZ_CP027352:4380346-4380422 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0F3WCK2

Antitoxin