Detailed information of TA system TA098150

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 112242..112495
• Replicon: plasmid unnamed
• Accession: NZ_CP027343
• Organism: Escherichia coli strain 2014C-4587

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: A0A148HBD8
• Locus tag: C6N23_RS26860
• Protein ID: WP_001336447.1
• Coordinates: 112242..112391 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	112439..112495 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6N23_RS26820	109327..109566	-	240	WP_001365702.1	MarR family transcriptional regulator	-
C6N23_RS26825	109579..109839	-	261	WP_072122678.1	hypothetical protein	-
C6N23_RS26840	110542..111399	-	858	WP_000130991.1	incFII family plasmid replication initiator RepA	-
C6N23_RS26845	111392..111466	-	75	WP_001365705.1	RepA leader peptide Tap	-
C6N23_RS26855	111701..111958	-	258	WP_000084404.1	replication regulatory protein RepA	-
C6N23_RS26860	112242..112391	-	150	WP_001336447.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	112439..112495	+	57	NuclAT_1	-	Antitoxin
-	112439..112495	+	57	NuclAT_1	-	Antitoxin
-	112439..112495	+	57	NuclAT_1	-	Antitoxin
-	112439..112495	+	57	NuclAT_1	-	Antitoxin
C6N23_RS26870	112670..113053	-	384	WP_001109065.1	hypothetical protein	-
C6N23_RS26875	113156..113617	-	462	WP_052892071.1	thermonuclease family protein	-
C6N23_RS26885	114716..115273	-	558	WP_000139380.1	fertility inhibition protein FinO	-
C6N23_RS26890	115309..115677	-	369	WP_000722534.1	NirD/YgiW/YdeI family stress tolerance protein	-
C6N23_RS26895	115760..116506	-	747	WP_000205708.1	type-F conjugative transfer system pilin acetylase TraX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	hlyD / hlyB / hlyA / hlyC / espP	1..131410	131410

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-45)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5572.69 Da
• Isoelectric Point: 8.7678

>T98150 WP_001336447.1 NZ_CP027343:c112391-112242 [Escherichia coli]
MTKYTLIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 150 bp

>T98150 NZ_CP027343:c112391-112242 [Escherichia coli]
ATGACGAAATATACCCTTATTGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 57 bp

>AT98150 NZ_CP027343:112439-112495 [Escherichia coli]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A148HBD8

Antitoxin