98064

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 545815..546610 Replicon chromosome
Accession NZ_CP027338
Organism Escherichia coli strain 2014C-3051

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag C6N28_RS03105 Protein ID WP_000854914.1
Coordinates 546236..546610 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag C6N28_RS03100 Protein ID WP_001280953.1
Coordinates 545815..546189 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6N28_RS03060 541170..542075 + 906 WP_000203541.1 chemotaxis protein -
C6N28_RS03065 542072..543142 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
C6N28_RS03080 543482..544300 + 819 WP_001234682.1 DUF945 domain-containing protein -
C6N28_RS03085 544391..544876 + 486 WP_000214398.1 antirestriction protein -
C6N28_RS03090 544892..545368 + 477 WP_001186738.1 RadC family protein -
C6N28_RS03095 545431..545652 + 222 WP_000692323.1 DUF987 domain-containing protein -
C6N28_RS03100 545815..546189 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6N28_RS03105 546236..546610 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
C6N28_RS03110 546607..547098 + 492 WP_000976857.1 hypothetical protein -
C6N28_RS03115 547110..547307 + 198 WP_000839282.1 DUF957 domain-containing protein -
C6N28_RS03120 547392..548234 + 843 WP_001280481.1 DUF4942 domain-containing protein -
C6N28_RS03130 548705..549643 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
C6N28_RS03135 549698..550435 + 738 WP_000283664.1 zinc-binding phosphatase -
C6N28_RS03140 550459..551013 + 555 WP_001001902.1 molecular chaperone YcdY -
C6N28_RS03145 551115..551606 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 544892..557171 12279


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T98064 WP_000854914.1 NZ_CP027338:546236-546610 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T98064 NZ_CP027338:546236-546610 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT98064 WP_001280953.1 NZ_CP027338:545815-546189 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT98064 NZ_CP027338:545815-546189 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References