Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4704780..4705005 Replicon chromosome
Accession NZ_CP027319
Organism Escherichia coli strain 2014C-3084

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag AAG01_RS22995 Protein ID WP_000813254.1
Coordinates 4704850..4705005 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 4704780..4704838 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AAG01_RS22965 4699852..4699992 + 141 Protein_4496 Rha family transcriptional regulator -
AAG01_RS22970 4700064..4701146 + 1083 WP_032313415.1 phage replisome organizer -
AAG01_RS22975 4701153..4701899 + 747 WP_000788742.1 ATP-binding protein -
AAG01_RS22980 4701921..4702691 + 771 WP_000451007.1 DUF1627 domain-containing protein -
AAG01_RS22985 4702707..4703120 + 414 WP_001151233.1 DUF977 family protein -
AAG01_RS22990 4703472..4704245 - 774 WP_000160654.1 alpha/beta hydrolase -
AAG01_RS24225 4704507..4704590 + 84 Protein_4502 ORF6N domain-containing protein -
- 4704780..4704838 - 59 - - Antitoxin
AAG01_RS22995 4704850..4705005 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
AAG01_RS23000 4705173..4705451 + 279 WP_001341388.1 hypothetical protein -
AAG01_RS23005 4705453..4706502 + 1050 WP_001265141.1 DUF968 domain-containing protein -
AAG01_RS23010 4706515..4706886 + 372 WP_001217436.1 RusA family crossover junction endodeoxyribonuclease -
AAG01_RS23015 4706876..4707247 + 372 WP_000090265.1 antiterminator Q family protein -
AAG01_RS23020 4707399..4708217 + 819 WP_000265267.1 CPBP family intramembrane metalloprotease -
AAG01_RS23025 4708504..4708701 + 198 WP_000917737.1 hypothetical protein -
AAG01_RS23030 4708839..4709552 + 714 WP_000261909.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T97952 WP_000813254.1 NZ_CP027319:4704850-4705005 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T97952 NZ_CP027319:4704850-4705005 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT97952 NZ_CP027319:c4704838-4704780 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References