Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3605962..3606220 Replicon chromosome
Accession NZ_CP027319
Organism Escherichia coli strain 2014C-3084

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag AAG01_RS17850 Protein ID WP_000809168.1
Coordinates 3605962..3606114 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3606163..3606220 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AAG01_RS17830 3601203..3601916 - 714 WP_001102364.1 acidic protein MsyB -
AAG01_RS17835 3601942..3602346 - 405 WP_032315851.1 DUF2541 family protein -
AAG01_RS17840 3602723..3604639 + 1917 WP_000516135.1 molecular chaperone DnaK -
AAG01_RS17845 3604728..3605858 + 1131 WP_001118464.1 molecular chaperone DnaJ -
AAG01_RS17850 3605962..3606114 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3606163..3606220 + 58 - - Antitoxin
AAG01_RS17855 3606700..3607866 + 1167 WP_000681368.1 Na+/H+ antiporter NhaA -
AAG01_RS17860 3607932..3608831 + 900 WP_001338226.1 transcriptional activator NhaR -
AAG01_RS17865 3608869..3609828 - 960 WP_000871683.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - espX1 3605962..3615293 9331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T97948 WP_000809168.1 NZ_CP027319:c3606114-3605962 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T97948 NZ_CP027319:c3606114-3605962 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT97948 NZ_CP027319:3606163-3606220 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References