Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4477645..4478273 Replicon chromosome
Accession NZ_CP027300
Organism Serratia marcescens strain SGAir0764

Toxin (Protein)


Gene name higB Uniprot ID A0A8G2G488
Locus tag C1N78_RS21440 Protein ID WP_016930174.1
Coordinates 4477645..4477935 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C1N78_RS21445 Protein ID WP_016930175.1
Coordinates 4477950..4478273 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1N78_RS21430 4474219..4476240 + 2022 WP_033639320.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
C1N78_RS21435 4476275..4477414 - 1140 WP_016930173.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
C1N78_RS21440 4477645..4477935 + 291 WP_016930174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1N78_RS21445 4477950..4478273 + 324 WP_016930175.1 HigA family addiction module antidote protein Antitoxin
C1N78_RS21450 4478266..4478778 + 513 WP_016930176.1 M48 family metallopeptidase -
C1N78_RS21455 4478828..4479808 + 981 WP_110147435.1 Gfo/Idh/MocA family oxidoreductase -
C1N78_RS21460 4479810..4480541 + 732 WP_016930178.1 glutamine amidotransferase -
C1N78_RS21465 4480797..4481762 + 966 WP_028127587.1 TerC family protein -
C1N78_RS21470 4482026..4483261 + 1236 WP_110147436.1 serine/threonine transporter SstT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11645.30 Da        Isoelectric Point: 10.2782

>T97794 WP_016930174.1 NZ_CP027300:4477645-4477935 [Serratia marcescens]
MIKSFRDRYLEQFYLEGRRSRLIPGALERQLARKLDMLAAAQQERDLHHPTGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAAEKIYLDPHQDT

Download         Length: 291 bp

>T97794 NZ_CP027300:4477645-4477935 [Serratia marcescens]
ATGATTAAATCTTTCCGCGATCGCTATCTGGAGCAGTTCTATCTGGAAGGCAGGCGCAGCCGTCTGATCCCCGGCGCGCT
TGAGCGACAGTTGGCCAGAAAACTCGATATGTTGGCCGCCGCGCAGCAAGAGCGTGATTTGCATCACCCCACGGGTAACT
ATTACAAGCGGCTATCCGGACCATTTCAGGGATGGTCAAGTCTGCGCGTCAATATGCACTGGCGGCTGATGTTCCAGTGG
CGGCATGATGCCGCTGAAAAAATTTACCTCGATCCTCATCAAGATACCTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12240.92 Da        Isoelectric Point: 6.7208

>AT97794 WP_016930175.1 NZ_CP027300:4477950-4478273 [Serratia marcescens]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILRRNITHA

Download         Length: 324 bp

>AT97794 NZ_CP027300:4477950-4478273 [Serratia marcescens]
ATGTTGGAAACCACGACTCGCGAACCCACCACGGTGGGAGAAGTGCTGCAGGAAGAATATTTAACGCCGCTAGGCATCGG
CCAGGAGGAACTGGCAAAGGTATTGGGCGTCACCCGCGCCACCGTCAATCGCCTGTGCAACGGGCATCGACGCATGAGCG
TTGCCGAGGCCAATCTGTTTGCCGATCTGTTCGAAACGACCGCTGACTTTTGGCTAAACCTGCAGGCGGCGCACGATCGC
TGGGAAGCCAGACAGGCCGATGCGCAGCGTGTGCGGTTGCGGCCGATCAAAGAAATACTGAGGCGCAATATCACTCATGC
ATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References