Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 2516015..2516529 | Replicon | chromosome |
Accession | NZ_CP027297 | ||
Organism | Streptomyces sp. SGAir0924 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | A0A6I5MKQ7 |
Locus tag | C1N79_RS11280 | Protein ID | WP_019326161.1 |
Coordinates | 2516275..2516529 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A7Y6HA55 |
Locus tag | C1N79_RS11275 | Protein ID | WP_019326160.1 |
Coordinates | 2516015..2516278 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C1N79_RS11260 | 2511922..2512782 | + | 861 | WP_019326157.1 | phosphatase PAP2 family protein | - |
C1N79_RS11265 | 2512844..2515837 | - | 2994 | WP_137960891.1 | bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase | - |
C1N79_RS11275 | 2516015..2516278 | + | 264 | WP_019326160.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
C1N79_RS11280 | 2516275..2516529 | + | 255 | WP_019326161.1 | Txe/YoeB family addiction module toxin | Toxin |
C1N79_RS11285 | 2516573..2517022 | + | 450 | WP_019326162.1 | VOC family protein | - |
C1N79_RS11290 | 2517044..2517712 | - | 669 | WP_029393478.1 | TetR/AcrR family transcriptional regulator | - |
C1N79_RS11295 | 2517781..2518743 | + | 963 | WP_086876687.1 | NAD(P)-dependent alcohol dehydrogenase | - |
C1N79_RS11300 | 2518770..2520533 | - | 1764 | WP_137960892.1 | NAD+ synthase | - |
C1N79_RS11305 | 2520618..2521220 | - | 603 | WP_029393479.1 | DUF305 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9827.13 Da Isoelectric Point: 9.7377
>T97780 WP_019326161.1 NZ_CP027297:2516275-2516529 [Streptomyces sp. SGAir0924]
VRVAFTSHGWEDYVHWAESDRKMTRRINKLIADIGRDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPGDGELVVVQA
RYHY
VRVAFTSHGWEDYVHWAESDRKMTRRINKLIADIGRDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPGDGELVVVQA
RYHY
Download Length: 255 bp
>T97780 NZ_CP027297:2516275-2516529 [Streptomyces sp. SGAir0924]
GTGAGAGTCGCTTTCACGTCGCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGATGACCAGACGGAT
CAACAAGCTGATCGCCGACATCGGGCGCGATCCCTTCAAGGGCATCGGCAAGCCGGAGCCGCTGAAGGGGGACCTGTCGG
GCTACTGGTCGCGGCGCATCGACGACACGCACCGTCTGGTGTACAAGCCGGGCGACGGCGAACTGGTCGTCGTCCAGGCG
CGGTACCACTACTGA
GTGAGAGTCGCTTTCACGTCGCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGATGACCAGACGGAT
CAACAAGCTGATCGCCGACATCGGGCGCGATCCCTTCAAGGGCATCGGCAAGCCGGAGCCGCTGAAGGGGGACCTGTCGG
GCTACTGGTCGCGGCGCATCGACGACACGCACCGTCTGGTGTACAAGCCGGGCGACGGCGAACTGGTCGTCGTCCAGGCG
CGGTACCACTACTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9774.88 Da Isoelectric Point: 4.8784
>AT97780 WP_019326160.1 NZ_CP027297:2516015-2516278 [Streptomyces sp. SGAir0924]
MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPKNARRLLDSIAEAEAGEARHRELI
DPDAERA
MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPKNARRLLDSIAEAEAGEARHRELI
DPDAERA
Download Length: 264 bp
>AT97780 NZ_CP027297:2516015-2516278 [Streptomyces sp. SGAir0924]
ATGTCCATCACCGCCAGCGAAGCCCGTCAGAACCTCTTCCCGCTGATAGAGCAGGTCAACGAGGACCACGCCCCGGTGCA
CATCACCTCCCGCAAGGGGAACGCCGTGCTGATGTCCGAGGAGGACTTCACGGCGTGGACGGAGACGGTGCACCTGCTGC
GGTCGCCGAAGAACGCCCGCCGTCTGCTCGATTCGATCGCGGAGGCCGAGGCCGGCGAGGCACGGCACCGCGAGCTGATC
GACCCGGACGCGGAGCGGGCGTGA
ATGTCCATCACCGCCAGCGAAGCCCGTCAGAACCTCTTCCCGCTGATAGAGCAGGTCAACGAGGACCACGCCCCGGTGCA
CATCACCTCCCGCAAGGGGAACGCCGTGCTGATGTCCGAGGAGGACTTCACGGCGTGGACGGAGACGGTGCACCTGCTGC
GGTCGCCGAAGAACGCCCGCCGTCTGCTCGATTCGATCGCGGAGGCCGAGGCCGGCGAGGCACGGCACCGCGAGCTGATC
GACCCGGACGCGGAGCGGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6I5MKQ7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7Y6HA55 |