Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2516015..2516529 Replicon chromosome
Accession NZ_CP027297
Organism Streptomyces sp. SGAir0924

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5MKQ7
Locus tag C1N79_RS11280 Protein ID WP_019326161.1
Coordinates 2516275..2516529 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7Y6HA55
Locus tag C1N79_RS11275 Protein ID WP_019326160.1
Coordinates 2516015..2516278 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1N79_RS11260 2511922..2512782 + 861 WP_019326157.1 phosphatase PAP2 family protein -
C1N79_RS11265 2512844..2515837 - 2994 WP_137960891.1 bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase -
C1N79_RS11275 2516015..2516278 + 264 WP_019326160.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
C1N79_RS11280 2516275..2516529 + 255 WP_019326161.1 Txe/YoeB family addiction module toxin Toxin
C1N79_RS11285 2516573..2517022 + 450 WP_019326162.1 VOC family protein -
C1N79_RS11290 2517044..2517712 - 669 WP_029393478.1 TetR/AcrR family transcriptional regulator -
C1N79_RS11295 2517781..2518743 + 963 WP_086876687.1 NAD(P)-dependent alcohol dehydrogenase -
C1N79_RS11300 2518770..2520533 - 1764 WP_137960892.1 NAD+ synthase -
C1N79_RS11305 2520618..2521220 - 603 WP_029393479.1 DUF305 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9827.13 Da        Isoelectric Point: 9.7377

>T97780 WP_019326161.1 NZ_CP027297:2516275-2516529 [Streptomyces sp. SGAir0924]
VRVAFTSHGWEDYVHWAESDRKMTRRINKLIADIGRDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPGDGELVVVQA
RYHY

Download         Length: 255 bp

>T97780 NZ_CP027297:2516275-2516529 [Streptomyces sp. SGAir0924]
GTGAGAGTCGCTTTCACGTCGCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGATGACCAGACGGAT
CAACAAGCTGATCGCCGACATCGGGCGCGATCCCTTCAAGGGCATCGGCAAGCCGGAGCCGCTGAAGGGGGACCTGTCGG
GCTACTGGTCGCGGCGCATCGACGACACGCACCGTCTGGTGTACAAGCCGGGCGACGGCGAACTGGTCGTCGTCCAGGCG
CGGTACCACTACTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9774.88 Da        Isoelectric Point: 4.8784

>AT97780 WP_019326160.1 NZ_CP027297:2516015-2516278 [Streptomyces sp. SGAir0924]
MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPKNARRLLDSIAEAEAGEARHRELI
DPDAERA

Download         Length: 264 bp

>AT97780 NZ_CP027297:2516015-2516278 [Streptomyces sp. SGAir0924]
ATGTCCATCACCGCCAGCGAAGCCCGTCAGAACCTCTTCCCGCTGATAGAGCAGGTCAACGAGGACCACGCCCCGGTGCA
CATCACCTCCCGCAAGGGGAACGCCGTGCTGATGTCCGAGGAGGACTTCACGGCGTGGACGGAGACGGTGCACCTGCTGC
GGTCGCCGAAGAACGCCCGCCGTCTGCTCGATTCGATCGCGGAGGCCGAGGCCGGCGAGGCACGGCACCGCGAGCTGATC
GACCCGGACGCGGAGCGGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5MKQ7

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y6HA55

References