Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4884632..4885193 Replicon chromosome
Accession NZ_CP027255
Organism Escherichia coli strain EC11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C6C13_RS25175 Protein ID WP_170939106.1
Coordinates 4884930..4885193 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C6C13_RS25170 Protein ID WP_097746960.1
Coordinates 4884632..4884940 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6C13_RS25125 4880116..4880304 - 189 WP_000660644.1 hypothetical protein -
C6C13_RS25130 4880501..4880707 - 207 WP_000141091.1 hypothetical protein -
C6C13_RS25135 4880863..4881324 - 462 WP_069903241.1 helix-turn-helix transcriptional regulator -
C6C13_RS25140 4881470..4882159 - 690 WP_057697516.1 LexA family transcriptional regulator -
C6C13_RS25145 4882293..4882565 + 273 WP_057697517.1 helix-turn-helix domain-containing protein -
C6C13_RS25150 4882687..4882914 - 228 WP_000132761.1 hypothetical protein -
C6C13_RS26845 4883003..4883323 + 321 WP_000186943.1 hypothetical protein -
C6C13_RS25155 4883399..4883710 + 312 WP_000932280.1 hypothetical protein -
C6C13_RS25160 4883710..4884417 + 708 WP_057698633.1 Rha family transcriptional regulator -
C6C13_RS25165 4884437..4884613 + 177 WP_001197746.1 DUF4222 domain-containing protein -
C6C13_RS25170 4884632..4884940 - 309 WP_097746960.1 helix-turn-helix transcriptional regulator Antitoxin
C6C13_RS25175 4884930..4885193 - 264 WP_170939106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6C13_RS25180 4885125..4885943 + 819 WP_198652759.1 ash family protein -
C6C13_RS25185 4885940..4886164 + 225 WP_000621227.1 hypothetical protein -
C6C13_RS25190 4886161..4887087 + 927 WP_097746962.1 helix-turn-helix domain-containing protein -
C6C13_RS25195 4887098..4887976 + 879 WP_102420745.1 ATP-binding protein -
C6C13_RS25200 4887973..4889364 + 1392 WP_097746965.1 replicative DNA helicase -
C6C13_RS25205 4889361..4889618 + 258 WP_001064803.1 hypothetical protein -
C6C13_RS25210 4889618..4890001 + 384 WP_057780576.1 antitermination protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4880116..4898345 18229


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(2-81)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10091.78 Da        Isoelectric Point: 10.7767

>T97767 WP_170939106.1 NZ_CP027255:c4885193-4884930 [Escherichia coli]
MRARYQHLVERMKVYGSNLGEPHTSAFGNGLFELRIKGSDGIARVFYCTLAGKRIIMLHSFIKKTQKTPPAERQKAETRM
KEVKHDW

Download         Length: 264 bp

>T97767 NZ_CP027255:c4885193-4884930 [Escherichia coli]
ATGCGTGCCCGATACCAGCATCTTGTTGAACGCATGAAGGTATACGGCAGCAATCTCGGAGAACCTCATACCAGTGCTTT
CGGTAACGGGCTTTTCGAGCTTCGGATTAAAGGTAGTGATGGCATCGCACGCGTCTTTTACTGCACCCTGGCAGGAAAAC
GCATCATCATGCTGCATAGTTTCATCAAGAAGACTCAGAAAACCCCACCAGCCGAACGCCAAAAAGCTGAAACCAGAATG
AAGGAGGTAAAGCATGACTGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11254.00 Da        Isoelectric Point: 9.6887

>AT97767 WP_097746960.1 NZ_CP027255:c4884940-4884632 [Escherichia coli]
MTGKRNPLTITHDEMADKWMKDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEIAERMGTKATVISRMESNLASGVSG
PSFSTLKKFARATGKKLQIRFV

Download         Length: 309 bp

>AT97767 NZ_CP027255:c4884940-4884632 [Escherichia coli]
ATGACTGGTAAACGTAATCCGCTAACCATTACACATGATGAAATGGCTGATAAATGGATGAAGGATCCAGCTTTTAAAGC
AGAATACGACGCCATCGCCGACGAATTTGCGCTGCTTGATGAAATGCTGGCAGCACGTAAAGAAGCTGGTTTAACCCAGG
CTGAGATCGCTGAGCGTATGGGAACCAAAGCAACTGTCATCAGCAGAATGGAAAGTAATCTGGCGTCAGGTGTCAGTGGA
CCATCATTTTCCACACTGAAAAAATTTGCCCGCGCAACAGGAAAAAAACTCCAGATCCGCTTCGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References