Detailed information of TA system TA097723

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 24263..24921
• Replicon: plasmid p1_005078
• Accession: NZ_CP027243
• Organism: Acinetobacter baumannii strain WCHAB005078

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: C6N18_RS00200
• Protein ID: WP_000312250.1
• Coordinates: 24562..24921 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: C6N18_RS00195
• Protein ID: WP_001096429.1
• Coordinates: 24263..24562 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6N18_RS00155	20322..20579	+	258	WP_000834292.1	hypothetical protein	-
C6N18_RS00160	20584..21156	+	573	WP_032011345.1	hypothetical protein	-
C6N18_RS00165	21132..21311	+	180	WP_002081921.1	hypothetical protein	-
C6N18_RS00170	21328..21957	+	630	WP_002081923.1	hypothetical protein	-
C6N18_RS00175	21997..22506	+	510	WP_032018705.1	hypothetical protein	-
C6N18_RS00180	22587..23141	+	555	WP_000790086.1	hypothetical protein	-
C6N18_RS00185	23191..23727	+	537	WP_032010581.1	hypothetical protein	-
C6N18_RS00195	24263..24562	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
C6N18_RS00200	24562..24921	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C6N18_RS00205	25122..25688	+	567	WP_031948745.1	hypothetical protein	-
C6N18_RS00210	25737..25967	+	231	WP_045124240.1	hypothetical protein	-
C6N18_RS00215	25986..26684	+	699	WP_000873188.1	hypothetical protein	-
C6N18_RS00220	26822..27205	+	384	WP_032018724.1	hypothetical protein	-
C6N18_RS00225	27272..28030	+	759	WP_001053130.1	hypothetical protein	-
C6N18_RS00230	28082..28417	+	336	WP_000654056.1	hypothetical protein	-
C6N18_RS00240	29283..29597	+	315	WP_032011240.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..70796	70796

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T97723 WP_000312250.1 NZ_CP027243:c24921-24562 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T97723 NZ_CP027243:c24921-24562 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT97723 WP_001096429.1 NZ_CP027243:c24562-24263 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT97723 NZ_CP027243:c24562-24263 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA