Detailed information of TA system TA097721

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1789589..1790095
• Replicon: chromosome
• Accession: NZ_CP027236
• Organism: Actinomyces sp. oral taxon 897 strain F0631

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: C3V41_RS07240
• Protein ID: WP_106109709.1
• Coordinates: 1789589..1789843 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: C3V41_RS07245
• Protein ID: WP_106110730.1
• Coordinates: 1789844..1790095 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3V41_RS07220	1784939..1785751	-	813	WP_106109706.1	histidine phosphatase family protein	-
C3V41_RS07225	1785856..1786839	+	984	WP_106109707.1	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	-
C3V41_RS07230	1786875..1787711	-	837	WP_106109708.1	class I SAM-dependent methyltransferase	-
C3V41_RS07235	1787810..1789192	-	1383	WP_106110729.1	citrate synthase	-
C3V41_RS07240	1789589..1789843	-	255	WP_106109709.1	Txe/YoeB family addiction module toxin	Toxin
C3V41_RS07245	1789844..1790095	-	252	WP_106110730.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
C3V41_RS07250	1790163..1791377	-	1215	WP_106110731.1	succinyldiaminopimelate transaminase	-
C3V41_RS07255	1791507..1791857	-	351	WP_106109710.1	ferredoxin family protein	-
C3V41_RS07260	1792268..1794712	-	2445	WP_129591514.1	VanW family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9959.40 Da
• Isoelectric Point: 9.4767

>T97721 WP_106109709.1 NZ_CP027236:c1789843-1789589 [Actinomyces sp. oral taxon 897]
VRLVWDPGAWEDYKHWQRADRRVLKRVNTLIDACLRDPRAGIGKPERLMYGAPGAWSRRITDEHRLVYLVDGDDLVILQA
RYHY

Nucleotide

• Length: 255 bp

>T97721 NZ_CP027236:c1789843-1789589 [Actinomyces sp. oral taxon 897]
GTGAGGCTTGTCTGGGACCCCGGCGCCTGGGAGGACTACAAGCACTGGCAGAGAGCCGACCGGCGGGTCCTTAAGCGTGT
CAACACCCTGATCGACGCCTGCCTGCGTGACCCCCGCGCCGGCATAGGCAAGCCTGAGCGGCTTATGTACGGAGCCCCCG
GCGCCTGGTCGCGGCGTATCACTGACGAGCACCGTCTCGTCTACCTGGTCGACGGCGACGACCTCGTTATCCTCCAGGCG
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9462.59 Da
• Isoelectric Point: 5.1170

>AT97721 WP_106110730.1 NZ_CP027236:c1790095-1789844 [Actinomyces sp. oral taxon 897]
VSISVSQARRTLFPLIEQVTSDRVPVEIVSRKGSVVLMPADEYAAWQETAYLFRSPANARRLLDAYDRARAGRTEEHDLD
RED

Nucleotide

• Length: 252 bp

>AT97721 NZ_CP027236:c1790095-1789844 [Actinomyces sp. oral taxon 897]
GTGTCTATTAGCGTCAGCCAGGCACGCAGGACATTGTTCCCGCTCATTGAGCAGGTCACCAGTGACCGTGTGCCCGTGGA
GATCGTCTCACGGAAGGGCAGCGTCGTCCTCATGCCCGCTGACGAGTACGCGGCCTGGCAGGAGACCGCCTACCTGTTCC
GCTCCCCGGCCAACGCCCGCAGGCTGCTTGACGCCTATGACCGGGCGCGCGCGGGCCGGACCGAGGAGCACGACCTCGAC
CGGGAGGACTGA