97678

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1904592..1905387 Replicon chromosome
Accession NZ_CP027221
Organism Escherichia coli strain 2015C-3101

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag C6H98_RS09890 Protein ID WP_000854914.1
Coordinates 1905013..1905387 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag C6H98_RS09885 Protein ID WP_001280954.1
Coordinates 1904592..1904966 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H98_RS09850 1901599..1901919 + 321 WP_000149392.1 phospholipase -
C6H98_RS09865 1902259..1903077 + 819 WP_001234682.1 DUF945 domain-containing protein -
C6H98_RS09870 1903168..1903653 + 486 WP_000214398.1 antirestriction protein -
C6H98_RS09875 1903669..1904145 + 477 WP_001186738.1 RadC family protein -
C6H98_RS09880 1904208..1904429 + 222 WP_001220314.1 DUF987 domain-containing protein -
C6H98_RS09885 1904592..1904966 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6H98_RS09890 1905013..1905387 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
C6H98_RS09895 1905384..1905875 + 492 WP_000976857.1 hypothetical protein -
C6H98_RS09900 1905887..1906084 + 198 WP_000839282.1 DUF957 domain-containing protein -
C6H98_RS09905 1906169..1907011 + 843 WP_001280481.1 DUF4942 domain-containing protein -
C6H98_RS09915 1907482..1908420 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
C6H98_RS09920 1908475..1909212 + 738 WP_000283664.1 zinc-binding phosphatase -
C6H98_RS09925 1909236..1909790 + 555 WP_001001902.1 molecular chaperone YcdY -
C6H98_RS09930 1909892..1910383 + 492 WP_042352365.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1903669..1915948 12279


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T97678 WP_000854914.1 NZ_CP027221:1905013-1905387 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T97678 NZ_CP027221:1905013-1905387 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT97678 WP_001280954.1 NZ_CP027221:1904592-1904966 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT97678 NZ_CP027221:1904592-1904966 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References