Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2368..2953 Replicon plasmid unnamed4
Accession NZ_CP027186
Organism Acinetobacter baumannii strain AR_0052

Toxin (Protein)


Gene name higB Uniprot ID N8ZPD7
Locus tag CSB68_RS20960 Protein ID WP_000897309.1
Coordinates 2633..2953 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CSB68_RS20955 Protein ID WP_000369782.1
Coordinates 2368..2640 (-) Length 91 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB68_RS20940 28..774 + 747 Protein_0 hypothetical protein -
CSB68_RS20945 932..1363 - 432 WP_000042163.1 MarR family transcriptional regulator -
CSB68_RS20950 1370..1798 - 429 WP_000105988.1 organic hydroperoxide resistance protein -
CSB68_RS20955 2368..2640 - 273 WP_000369782.1 helix-turn-helix domain-containing protein Antitoxin
CSB68_RS20960 2633..2953 - 321 WP_000897309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSB68_RS20965 3140..3337 - 198 WP_000476222.1 hypothetical protein -
CSB68_RS20970 3404..3631 - 228 WP_000921865.1 hypothetical protein -
CSB68_RS20975 3729..3944 - 216 WP_000071892.1 cold-shock protein -
CSB68_RS20980 4278..4487 - 210 WP_000069474.1 hypothetical protein -
CSB68_RS20985 4480..4782 - 303 WP_001129974.1 XRE family transcriptional regulator -
CSB68_RS20990 4775..5131 - 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin -
CSB68_RS20995 5750..6178 + 429 WP_000105988.1 organic hydroperoxide resistance protein -
CSB68_RS21000 6185..6616 + 432 WP_000042163.1 MarR family transcriptional regulator -
CSB68_RS21005 6856..7374 - 519 WP_000839337.1 plasmid replication DNA-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..38505 38505


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(41-102)

Antitoxin

(37-85)


Sequences


Toxin        


Download         Length: 107 a.a.        Molecular weight: 12209.01 Da        Isoelectric Point: 7.9835

>T97585 WP_000897309.1 NZ_CP027186:c2953-2633 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T97585 NZ_CP027186:c2953-2633 [Acinetobacter baumannii]
ATGTTATTCATTGAAACCAGTATTTTTACTAAGCAAATCAAAGAGCTTGTGAGTGATGAAGAGTATCGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCTTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATTCTACGTCAATTAGTAAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10064.50 Da        Isoelectric Point: 7.2045

>AT97585 WP_000369782.1 NZ_CP027186:c2640-2368 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPGLI

Download         Length: 273 bp

>AT97585 NZ_CP027186:c2640-2368 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATCAAGCGTAATGAGATAAAGGCAAG
TCGAGTCACAGAGCTTGAATTACCGGATATTAAAGAAGTACGTGAGAAAACAGGCTTAACCCAGGCTGAATTTGCTGCAC
GTTTGCATATCAGTGCAAGAACCCTGCAAAACTGGGAACAAGGCCGTCGCTATCCGACTGGCCCAGCAGCAACTTTAATC
CGTATTCTTGATGCCCATCCAGGTCTGATTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A855WJQ3


Antitoxin

Source ID Structure

References