Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2535924..2536582 Replicon chromosome
Accession NZ_CP027177
Organism Morganella morganii strain AR_0057

Toxin (Protein)


Gene name higB Uniprot ID A0A447J593
Locus tag CSB69_RS11715 Protein ID WP_032098584.1
Coordinates 2535924..2536277 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID J7TDD0
Locus tag CSB69_RS11720 Protein ID WP_004236876.1
Coordinates 2536280..2536582 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB69_RS11705 2534103..2534360 - 258 WP_004236879.1 biofilm formation regulator BssS -
CSB69_RS11710 2534595..2535647 - 1053 WP_015422620.1 dihydroorotase -
CSB69_RS11715 2535924..2536277 + 354 WP_032098584.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSB69_RS11720 2536280..2536582 + 303 WP_004236876.1 XRE family transcriptional regulator Antitoxin
CSB69_RS11745 2537690..2538199 - 510 WP_004240013.1 YlaC family protein -
CSB69_RS11750 2538660..2538872 + 213 WP_004240014.1 transcription antiterminator/RNA stability regulator CspE -
CSB69_RS11755 2538976..2539170 + 195 WP_015422621.1 protein DsrB -
CSB69_RS11760 2539520..2540215 + 696 WP_004240015.1 MgtC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13620.58 Da        Isoelectric Point: 9.9631

>T97564 WP_032098584.1 NZ_CP027177:2535924-2536277 [Morganella morganii]
VWKIVTTDNFTAWFAEQDDGDRAAILAAMLVLEKRGPGLPRPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Download         Length: 354 bp

>T97564 NZ_CP027177:2535924-2536277 [Morganella morganii]
GTGTGGAAGATAGTCACAACAGATAATTTTACAGCGTGGTTTGCTGAGCAGGATGACGGAGATCGCGCAGCAATACTGGC
AGCGATGCTGGTATTGGAGAAGCGGGGACCCGGCTTACCAAGGCCGTATGCGGATACTGTAAAAGGTTCCCGGTATACGA
ATATGAAAGAGCTTCGTATACAGAGCAGGGGACAACCGATACGGGCATTTTTTGCATTCGACCCTGAGAGAAGAGGCGTC
TTGCTGTGTGCGGGGTATAAAACCGGCAAAGAAAAACGTTTTTATATGCAGATGATCCCGCAGGCTGACCGTGAGTATAC
AGAATGGCTGAACAGGCCGGAAAACAGGAGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11108.00 Da        Isoelectric Point: 9.5930

>AT97564 WP_004236876.1 NZ_CP027177:2536280-2536582 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVKKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Download         Length: 303 bp

>AT97564 NZ_CP027177:2536280-2536582 [Morganella morganii]
ATGGGAAAGTCACTCAGACAACTGCTGGCTGAGGAAAAGCCGGAAGTCGCGGCTGCTGCACGGGTTCAGGCGGATGAGAT
CCTGCTGAATATCCATCTGGCGGAGCTGCGGGAGAAAGTGAAGAAAACACAGGTGGAAATGGCGCAGGCACTGGGAATAA
AACAGCCGACAGTCGCAGGGATGGAAAAACCGGGGCGTGATGTCAAATTATCCACGCTGAGACGCTATGTGGATGCCATC
GGCGGAAAACTGAATATTGATGTTGAACTGCCGGACGGCACGCATTATATGTTCCGGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447J593

Antitoxin

Source ID Structure
AlphaFold DB J7TDD0

References