97543

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1191147..1191742 Replicon chromosome
Accession NZ_CP027172
Organism Pseudomonas aeruginosa strain AR_0353

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag CSB90_RS05540 Protein ID WP_003113526.1
Coordinates 1191147..1191425 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CSB90_RS05545 Protein ID WP_003133769.1
Coordinates 1191437..1191742 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB90_RS05520 1186572..1187810 + 1239 WP_003095023.1 C69 family dipeptidase -
CSB90_RS05525 1187872..1188519 + 648 WP_003095021.1 carbonate dehydratase -
CSB90_RS05530 1188590..1190818 - 2229 WP_003133778.1 TonB-dependent receptor -
CSB90_RS05540 1191147..1191425 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSB90_RS05545 1191437..1191742 + 306 WP_003133769.1 HigA family addiction module antidote protein Antitoxin
CSB90_RS05550 1192185..1193177 + 993 WP_003133766.1 hypothetical protein -
CSB90_RS05555 1193261..1194526 - 1266 WP_023094906.1 nucleotidyltransferase -
CSB90_RS35570 1194523..1195113 - 591 WP_071536478.1 SLATT domain-containing protein -
CSB90_RS05560 1195207..1195542 - 336 WP_023094905.1 hypothetical protein -
CSB90_RS05570 1195982..1196254 + 273 WP_004352675.1 hypothetical protein -
CSB90_RS05575 1196430..1196720 + 291 WP_031757220.1 DUF5447 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T97543 WP_003113526.1 NZ_CP027172:1191147-1191425 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T97543 NZ_CP027172:1191147-1191425 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT97543 WP_003133769.1 NZ_CP027172:1191437-1191742 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT97543 NZ_CP027172:1191437-1191742 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTACGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCCCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References