Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3127453..3127955 Replicon chromosome
Accession NZ_CP027134
Organism Escherichia coli strain AR_0372

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag CSC09_RS18100 Protein ID WP_000767829.1
Coordinates 3127453..3127707 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag CSC09_RS18105 Protein ID WP_001259255.1
Coordinates 3127704..3127955 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC09_RS18070 3122468..3122695 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
CSC09_RS18075 3122709..3123767 - 1059 WP_000492324.1 transport protein YeeE -
CSC09_RS18080 3123946..3125304 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
CSC09_RS18085 3125294..3125356 - 63 WP_010723108.1 membrane protein YoeI -
CSC09_RS18090 3125571..3126500 - 930 WP_023154044.1 LysR family transcriptional regulator -
CSC09_RS18095 3126546..3127370 - 825 WP_000754758.1 SDR family oxidoreductase -
CSC09_RS18100 3127453..3127707 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
CSC09_RS18105 3127704..3127955 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
CSC09_RS18110 3128238..3128288 + 51 WP_001364200.1 his operon leader peptide -
CSC09_RS18120 3128434..3129333 + 900 WP_021523143.1 ATP phosphoribosyltransferase -
CSC09_RS18125 3129339..3130643 + 1305 WP_021523144.1 histidinol dehydrogenase -
CSC09_RS18130 3130640..3131710 + 1071 WP_000108937.1 histidinol-phosphate transaminase -
CSC09_RS18135 3131710..3132777 + 1068 WP_000080136.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T97429 WP_000767829.1 NZ_CP027134:c3127707-3127453 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T97429 NZ_CP027134:c3127707-3127453 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT97429 WP_001259255.1 NZ_CP027134:c3127955-3127704 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT97429 NZ_CP027134:c3127955-3127704 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References