Detailed information of TA system TA097357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 67254..67912
• Replicon: plasmid unnamed2
• Accession: NZ_CP027121
• Organism: Acinetobacter baumannii strain AR_0056

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: C7R87_RS00440
• Protein ID: WP_000312250.1
• Coordinates: 67254..67613 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: C7R87_RS00445
• Protein ID: WP_001096429.1
• Coordinates: 67613..67912 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7R87_RS00405	62775..63089	-	315	WP_000708714.1	hypothetical protein	-
C7R87_RS00415	64144..64902	-	759	WP_001053127.1	hypothetical protein	-
C7R87_RS00420	64969..65352	-	384	WP_000654348.1	hypothetical protein	-
C7R87_RS00425	65491..66189	-	699	WP_000873188.1	hypothetical protein	-
C7R87_RS00430	66256..66438	-	183	WP_000373385.1	hypothetical protein	-
C7R87_RS00435	66487..67053	-	567	WP_000710385.1	hypothetical protein	-
C7R87_RS00440	67254..67613	+	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C7R87_RS00445	67613..67912	+	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
C7R87_RS00455	68450..68986	-	537	WP_000731978.1	hypothetical protein	-
C7R87_RS00460	69036..69590	-	555	WP_000790084.1	hypothetical protein	-
C7R87_RS00465	69610..69828	-	219	WP_001043201.1	hypothetical protein	-
C7R87_RS00470	69868..70497	-	630	WP_000701004.1	hypothetical protein	-
C7R87_RS00475	70514..70693	-	180	WP_000387630.1	hypothetical protein	-
C7R87_RS00480	70669..71241	-	573	WP_000443897.1	hypothetical protein	-
C7R87_RS00485	71246..71503	-	258	WP_000834290.1	hypothetical protein	-
C7R87_RS00490	71608..72060	-	453	Protein_91	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	blaOXA-23	-	1..72105	72105

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T97357 WP_000312250.1 NZ_CP027121:67254-67613 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T97357 NZ_CP027121:67254-67613 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT97357 WP_001096429.1 NZ_CP027121:67613-67912 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT97357 NZ_CP027121:67613-67912 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA