Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2816846..2817348 Replicon chromosome
Accession NZ_CP027103
Organism Escherichia coli strain RM14723

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag C5099_RS14915 Protein ID WP_000767829.1
Coordinates 2816846..2817100 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag C5099_RS14920 Protein ID WP_001358091.1
Coordinates 2817097..2817348 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5099_RS14895 2813339..2814697 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
C5099_RS14900 2814687..2814749 - 63 WP_097433929.1 membrane protein YoeI -
C5099_RS14905 2814964..2815893 - 930 WP_000803366.1 LysR family transcriptional regulator -
C5099_RS14910 2815939..2816763 - 825 WP_000754737.1 SDR family oxidoreductase -
C5099_RS14915 2816846..2817100 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
C5099_RS14920 2817097..2817348 - 252 WP_001358091.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C5099_RS14925 2817631..2817681 + 51 WP_001364200.1 his operon leader peptide -
C5099_RS14935 2817827..2818726 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
C5099_RS14940 2818732..2820036 + 1305 WP_001358092.1 histidinol dehydrogenase -
C5099_RS14945 2820033..2821103 + 1071 WP_001358093.1 histidinol-phosphate transaminase -
C5099_RS14950 2821103..2822170 + 1068 WP_001358094.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T97259 WP_000767829.1 NZ_CP027103:c2817100-2816846 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T97259 NZ_CP027103:c2817100-2816846 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9323.58 Da        Isoelectric Point: 4.7954

>AT97259 WP_001358091.1 NZ_CP027103:c2817348-2817097 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGESCVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT97259 NZ_CP027103:c2817348-2817097 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGTCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References