Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 3753..4410 | Replicon | plasmid IncAC2 |
| Accession | NZ_CP027055 | ||
| Organism | Klebsiella pneumoniae strain 2_GR_12 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | A6D68_RS28825 | Protein ID | WP_000270043.1 |
| Coordinates | 3753..4103 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | A6D68_RS28830 | Protein ID | WP_000124640.1 |
| Coordinates | 4108..4410 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A6D68_RS28785 | 227..724 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| A6D68_RS28790 | 727..1215 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| A6D68_RS28795 | 1312..1647 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| A6D68_RS28800 | 1662..2132 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| A6D68_RS28805 | 2125..2496 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| A6D68_RS28810 | 2507..2701 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| A6D68_RS28820 | 3042..3590 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| A6D68_RS28825 | 3753..4103 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| A6D68_RS28830 | 4108..4410 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| A6D68_RS28835 | 4437..4730 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| A6D68_RS28840 | 4818..5090 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| A6D68_RS28845 | 5148..5675 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| A6D68_RS28855 | 5906..6763 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| A6D68_RS28860 | 6750..6980 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| A6D68_RS28865 | 6980..7498 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| A6D68_RS28870 | 7495..7941 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| A6D68_RS28875 | 7941..8300 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| A6D68_RS28880 | 8357..8785 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / blaTEM-1A / rmtB / tet(G) / floR / qacE / ant(3'')-Ia / blaOXA-10 / cmlA1 / ARR-3 / ant(2'')-Ia / blaVEB-1 / dfrA23 / dfrA14 | - | 1..175636 | 175636 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T97188 WP_000270043.1 NZ_CP027055:3753-4103 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T97188 NZ_CP027055:3753-4103 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT97188 WP_000124640.1 NZ_CP027055:4108-4410 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT97188 NZ_CP027055:4108-4410 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|