Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 114692..115349 | Replicon | plasmid IncAC2 |
| Accession | NZ_CP027043 | ||
| Organism | Klebsiella pneumoniae strain 1_GR_13 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | A6D67_RS26340 | Protein ID | WP_000270043.1 |
| Coordinates | 114999..115349 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | A6D67_RS26335 | Protein ID | WP_000124640.1 |
| Coordinates | 114692..114994 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A6D67_RS26285 | 110317..110745 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| A6D67_RS26290 | 110802..111161 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| A6D67_RS26295 | 111161..111607 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| A6D67_RS26300 | 111604..112122 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| A6D67_RS26305 | 112122..112352 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| A6D67_RS26310 | 112339..113196 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| A6D67_RS26320 | 113427..113954 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| A6D67_RS26325 | 114012..114284 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| A6D67_RS26330 | 114372..114665 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| A6D67_RS26335 | 114692..114994 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| A6D67_RS26340 | 114999..115349 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| A6D67_RS26345 | 115512..116060 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| A6D67_RS26355 | 116401..116595 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| A6D67_RS26360 | 116606..116977 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| A6D67_RS26365 | 116970..117440 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| A6D67_RS26370 | 117455..117790 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| A6D67_RS26375 | 117887..118375 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| A6D67_RS26380 | 118378..118875 | + | 498 | WP_000062185.1 | hypothetical protein | - |
| A6D67_RS26390 | 119090..119794 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| A6D67_RS26395 | 119858..120094 | - | 237 | Protein_144 | ATP-binding cassette domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul2 / dfrA14 / dfrA23 / blaVEB-1 / ant(2'')-Ia / ARR-3 / cmlA1 / blaOXA-10 / ant(3'')-Ia / qacE / floR / tet(G) / rmtB / blaTEM-1B / tet(A) / aph(6)-Id / aph(3'')-Ib | - | 1..192771 | 192771 | |
| - | flank | IS/Tn | - | - | 119090..119794 | 704 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T97147 WP_000270043.1 NZ_CP027043:c115349-114999 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T97147 NZ_CP027043:c115349-114999 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT97147 WP_000124640.1 NZ_CP027043:c114994-114692 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT97147 NZ_CP027043:c114994-114692 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|