Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1871040..1871581 Replicon chromosome
Accession NZ_CP027027
Organism Shigella dysenteriae strain E670/74

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag C5S64_RS09850 Protein ID WP_000615975.1
Coordinates 1871040..1871318 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag C5S64_RS09855 Protein ID WP_000729704.1
Coordinates 1871321..1871581 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5S64_RS09835 1868623..1869201 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
C5S64_RS09840 1869407..1870173 + 767 Protein_1772 class II glutamine amidotransferase -
C5S64_RS09845 1870144..1870884 - 741 WP_001225684.1 murein L,D-transpeptidase -
C5S64_RS09850 1871040..1871318 - 279 WP_000615975.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
C5S64_RS09855 1871321..1871581 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
C5S64_RS09860 1871767..1872540 + 774 WP_000543886.1 C40 family peptidase -
C5S64_RS09865 1872594..1874306 - 1713 Protein_1777 flagellar biosynthesis protein FlhA -
C5S64_RS09870 1874278..1875063 + 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
C5S64_RS09875 1875215..1875985 - 771 WP_000640586.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10853.66 Da        Isoelectric Point: 10.0703

>T97022 WP_000615975.1 NZ_CP027027:c1871318-1871040 [Shigella dysenteriae]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINHTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T97022 NZ_CP027027:c1871318-1871040 [Shigella dysenteriae]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAAGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATCATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT97022 WP_000729704.1 NZ_CP027027:c1871581-1871321 [Shigella dysenteriae]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT97022 NZ_CP027027:c1871581-1871321 [Shigella dysenteriae]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References