Detailed information of TA system TA097015

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 1518621..1519033
• Replicon: chromosome
• Accession: NZ_CP027027
• Organism: Shigella dysenteriae strain E670/74

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: C5S64_RS08065
• Protein ID: WP_000132622.1
• Coordinates: 1518621..1518962 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	1518957..1519033 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5S64_RS08045	1514225..1514965	-	741	Protein_1441	IS5 family transposase	-
C5S64_RS08050	1515027..1516043	-	1017	Protein_1442	PLP-dependent aminotransferase family protein	-
C5S64_RS08055	1516220..1516384	+	165	WP_000394268.1	DUF1127 domain-containing protein	-
C5S64_RS08060	1516481..1518574	+	2094	WP_000648227.1	DUF262 domain-containing protein	-
C5S64_RS08065	1518621..1518962	-	342	WP_000132622.1	endoribonuclease SymE	Toxin
-	1518957..1519033	+	77	NuclAT_20	-	Antitoxin
-	1518957..1519033	+	77	NuclAT_20	-	Antitoxin
-	1518957..1519033	+	77	NuclAT_20	-	Antitoxin
-	1518957..1519033	+	77	NuclAT_20	-	Antitoxin
-	1518957..1519033	+	77	NuclAT_21	-	Antitoxin
-	1518957..1519033	+	77	NuclAT_21	-	Antitoxin
-	1518957..1519033	+	77	NuclAT_21	-	Antitoxin
-	1518957..1519033	+	77	NuclAT_21	-	Antitoxin
C5S64_RS08070	1519183..1520919	-	1737	WP_000110085.1	restriction endonuclease subunit S	-
C5S64_RS08075	1520919..1522388	-	1470	WP_004996206.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1516481..1526818	10337

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12340.11 Da
• Isoelectric Point: 7.8227

>T97015 WP_000132622.1 NZ_CP027027:c1518962-1518621 [Shigella dysenteriae]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQSPAPEESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T97015 NZ_CP027027:c1518962-1518621 [Shigella dysenteriae]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCGCCATCACTCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCTCAATCACCCGCCCCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCACGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTAATTGC
TGGTAAACAGAAAGTTGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT97015 NZ_CP027027:1518957-1519033 [Shigella dysenteriae]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin