Detailed information of TA system TA096999

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1582018..1582673
• Replicon: chromosome
• Accession: NZ_CP026996
• Organism: Bordetella pertussis strain I182

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: CY776_RS07765
• Protein ID: WP_047122780.1
• Coordinates: 1582018..1582269 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: CY776_RS07770
• Protein ID: WP_003809516.1
• Coordinates: 1582272..1582673 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CY776_RS07740	1577179..1578309	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
CY776_RS07745	1578544..1579125	+	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
CY776_RS07750	1579262..1580326	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
CY776_RS07755	1580411..1580857	-	447	WP_003819827.1	GFA family protein	-
CY776_RS07760	1581082..1581963	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
CY776_RS07765	1582018..1582269	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CY776_RS07770	1582272..1582673	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CY776_RS07775	1582693..1582929	+	237	WP_010930404.1	membrane protein	-
CY776_RS07780	1582937..1583416	+	480	WP_010930405.1	disulfide bond formation protein B	-
CY776_RS07785	1583566..1584081	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
CY776_RS07790	1584084..1585274	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
CY776_RS07795	1585294..1586331	+	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
CY776_RS07800	1586468..1587490	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T96999 WP_047122780.1 NZ_CP026996:1582018-1582269 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T96999 NZ_CP026996:1582018-1582269 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT96999 WP_003809516.1 NZ_CP026996:1582272-1582673 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT96999 NZ_CP026996:1582272-1582673 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6