Detailed information of TA system TA096991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2526664..2527319
• Replicon: chromosome
• Accession: NZ_CP026989
• Organism: Bordetella pertussis strain J246

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: CG053_RS12295
• Protein ID: WP_047122780.1
• Coordinates: 2527068..2527319 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: CG053_RS12290
• Protein ID: WP_003809516.1
• Coordinates: 2526664..2527065 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CG053_RS12260	2521847..2522869	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
CG053_RS12265	2523006..2524043	-	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
CG053_RS12270	2524063..2525253	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
CG053_RS12275	2525256..2525771	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
CG053_RS12280	2525921..2526400	-	480	WP_010930405.1	disulfide bond formation protein B	-
CG053_RS12285	2526408..2526644	-	237	WP_010930404.1	membrane protein	-
CG053_RS12290	2526664..2527065	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
CG053_RS12295	2527068..2527319	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
CG053_RS12300	2527374..2528255	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
CG053_RS12305	2528480..2528926	+	447	WP_003819827.1	GFA family protein	-
CG053_RS12310	2529011..2530075	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
CG053_RS12315	2530212..2530793	-	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
CG053_RS12320	2531028..2532158	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T96991 WP_047122780.1 NZ_CP026989:c2527319-2527068 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T96991 NZ_CP026989:c2527319-2527068 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT96991 WP_003809516.1 NZ_CP026989:c2527065-2526664 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT96991 NZ_CP026989:c2527065-2526664 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6