Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 615447..615949 Replicon chromosome
Accession NZ_CP026985
Organism Pectobacterium parmentieri strain IFB5619

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8B3FFY4
Locus tag C5E25_RS02990 Protein ID WP_025919527.1
Coordinates 615447..615701 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A8B3FIJ8
Locus tag C5E25_RS02995 Protein ID WP_033070807.1
Coordinates 615698..615949 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5E25_RS02970 610553..611815 - 1263 WP_012822274.1 L-rhamnose isomerase -
C5E25_RS02975 611812..613302 - 1491 WP_012822275.1 rhamnulokinase -
C5E25_RS02980 613671..614510 + 840 WP_005971146.1 HTH-type transcriptional activator RhaS -
C5E25_RS02985 614535..615389 + 855 WP_012822276.1 helix-turn-helix domain-containing protein -
C5E25_RS02990 615447..615701 - 255 WP_025919527.1 Txe/YoeB family addiction module toxin Toxin
C5E25_RS02995 615698..615949 - 252 WP_033070807.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C5E25_RS03000 616024..617712 - 1689 WP_025919529.1 ABC transporter ATP-binding protein -
C5E25_RS03005 617709..618575 - 867 WP_012822280.1 ABC transporter permease -
C5E25_RS03010 618568..619527 - 960 WP_012822281.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtB / hcp 532080..675143 143063


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10135.66 Da        Isoelectric Point: 8.0367

>T96983 WP_025919527.1 NZ_CP026985:c615701-615447 [Pectobacterium parmentieri]
VKPIWSEAAWEDYLYWQDIDNRIVKKINELIKEIRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITDDAMMIAAC
RYHY

Download         Length: 255 bp

>T96983 NZ_CP026985:c615701-615447 [Pectobacterium parmentieri]
GTGAAGCCAATCTGGTCAGAAGCAGCATGGGAAGACTACCTGTACTGGCAGGATATCGATAATCGGATAGTCAAAAAAAT
CAATGAATTAATAAAAGAAATTCGCAGAACGCCTTTTGAGGGAAAAGGAAAACCAGAGCCGCTTAAACATAATCTTGCTG
GCTTCTGGTCACGCCGTATCACCGAAGAACATCGTCTGGTCTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9351.64 Da        Isoelectric Point: 4.6119

>AT96983 WP_033070807.1 NZ_CP026985:c615949-615698 [Pectobacterium parmentieri]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNAIESLKAGNGEERD
IIE

Download         Length: 252 bp

>AT96983 NZ_CP026985:c615949-615698 [Pectobacterium parmentieri]
ATGCGTACAATTAGCTACAGCGAAGCCCGCCAAAACCTATCAGCAACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACCCGACAGAATGGCGAAGCCTGTGTGCTGATGTCTCTGGAAGAGTATAACTCTCTAGAAGAAACCGCGTATT
TACTGCGTTCTCCCGCCAATGCCAAAAGACTGATGAATGCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3FFY4

Antitoxin

Source ID Structure
AlphaFold DB A0A8B3FIJ8

References