Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 615301..615803 Replicon chromosome
Accession NZ_CP026983
Organism Pectobacterium parmentieri strain IFB5604

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8B3FFY4
Locus tag C5E23_RS02975 Protein ID WP_025919527.1
Coordinates 615301..615555 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A8B3FIJ8
Locus tag C5E23_RS02980 Protein ID WP_033070807.1
Coordinates 615552..615803 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5E23_RS02955 610407..611669 - 1263 WP_012822274.1 L-rhamnose isomerase -
C5E23_RS02960 611666..613156 - 1491 WP_012822275.1 rhamnulokinase -
C5E23_RS02965 613525..614364 + 840 WP_005971146.1 HTH-type transcriptional activator RhaS -
C5E23_RS02970 614389..615243 + 855 WP_012822276.1 helix-turn-helix domain-containing protein -
C5E23_RS02975 615301..615555 - 255 WP_025919527.1 Txe/YoeB family addiction module toxin Toxin
C5E23_RS02980 615552..615803 - 252 WP_033070807.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C5E23_RS02985 615878..617566 - 1689 WP_025919529.1 ABC transporter ATP-binding protein -
C5E23_RS02990 617563..618429 - 867 WP_012822280.1 ABC transporter permease -
C5E23_RS02995 618422..619381 - 960 WP_012822281.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtB / hcp 531934..674704 142770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-84)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 10135.66 Da        Isoelectric Point: 8.0367

>T96973 WP_025919527.1 NZ_CP026983:c615555-615301 [Pectobacterium parmentieri]
VKPIWSEAAWEDYLYWQDIDNRIVKKINELIKEIRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITDDAMMIAAC
RYHY

Download         Length: 255 bp

>T96973 NZ_CP026983:c615555-615301 [Pectobacterium parmentieri]
GTGAAGCCAATCTGGTCAGAAGCAGCATGGGAAGACTACCTGTACTGGCAGGATATCGATAATCGGATAGTCAAAAAAAT
CAATGAATTAATAAAAGAAATTCGCAGAACGCCTTTTGAGGGAAAAGGAAAACCAGAGCCGCTTAAACATAATCTTGCTG
GCTTCTGGTCACGCCGTATCACCGAAGAACATCGTCTGGTCTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9351.64 Da        Isoelectric Point: 4.6119

>AT96973 WP_033070807.1 NZ_CP026983:c615803-615552 [Pectobacterium parmentieri]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNAIESLKAGNGEERD
IIE

Download         Length: 252 bp

>AT96973 NZ_CP026983:c615803-615552 [Pectobacterium parmentieri]
ATGCGTACAATTAGCTACAGCGAAGCCCGCCAAAACCTATCAGCAACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACCCGACAGAATGGCGAAGCCTGTGTGCTGATGTCTCTGGAAGAGTATAACTCTCTAGAAGAAACCGCGTATT
TACTGCGTTCTCCCGCCAATGCCAAAAGACTGATGAATGCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A8B3FFY4


Antitoxin

Source ID Structure
AlphaFold DB A0A8B3FIJ8

References