Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 482164..482789 Replicon chromosome
Accession NZ_CP026983
Organism Pectobacterium parmentieri strain IFB5604

Toxin (Protein)


Gene name higB Uniprot ID A0A8B3FNM7
Locus tag C5E23_RS02405 Protein ID WP_033070820.1
Coordinates 482164..482469 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C5E23_RS02410 Protein ID WP_103808699.1
Coordinates 482466..482789 (+) Length 108 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5E23_RS02380 477886..478533 + 648 WP_012822190.1 type I-E CRISPR-associated protein Cas6/Cse3/CasE -
C5E23_RS02385 478561..479478 + 918 WP_012822191.1 type I-E CRISPR-associated endonuclease Cas1 -
C5E23_RS02390 479479..479772 + 294 WP_005973730.1 type I-E CRISPR-associated endoribonuclease Cas2 -
C5E23_RS02395 481307..481678 - 372 WP_103808702.1 helix-turn-helix domain-containing protein -
C5E23_RS02400 481752..482012 - 261 WP_012822193.1 type II toxin-antitoxin system RelE/ParE family toxin -
C5E23_RS02405 482164..482469 + 306 WP_033070820.1 type II toxin-antitoxin system HigB family toxin Toxin
C5E23_RS02410 482466..482789 + 324 WP_103808699.1 helix-turn-helix domain-containing protein Antitoxin
C5E23_RS02415 483952..484410 + 459 WP_012822197.1 hypothetical protein -
C5E23_RS02420 484491..485843 - 1353 WP_103808643.1 aspartate aminotransferase family protein -
C5E23_RS02425 485874..487145 - 1272 WP_103808673.1 MFS transporter -
C5E23_RS02430 487300..487746 + 447 WP_012822200.1 helix-turn-helix transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 102 a.a.        Molecular weight: 12010.78 Da        Isoelectric Point: 10.0386

>T96970 WP_033070820.1 NZ_CP026983:482164-482469 [Pectobacterium parmentieri]
VFSRAPFDTAIAQFPNQAAALADLYRTIKREIYATPDDMKKRFPSLDRMKYREKWWVIDIGGGHLRVMFFADFERGKIFI
KHITSHAEYGSLTEYYRRNKE

Download         Length: 306 bp

>T96970 NZ_CP026983:482164-482469 [Pectobacterium parmentieri]
GTGTTCTCCCGTGCACCTTTTGACACTGCAATCGCCCAATTCCCGAATCAGGCGGCAGCACTGGCTGACCTATACCGGAC
GATAAAGCGTGAAATATATGCAACGCCGGACGATATGAAAAAACGTTTCCCCAGCTTAGACAGGATGAAGTACAGGGAAA
AGTGGTGGGTTATTGATATTGGTGGTGGGCATCTTCGGGTGATGTTTTTCGCTGATTTTGAGCGAGGGAAAATTTTTATC
AAACACATCACATCCCATGCAGAGTACGGCAGTCTGACAGAATATTACCGGAGGAATAAAGAATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11655.44 Da        Isoelectric Point: 5.0877

>AT96970 WP_103808699.1 NZ_CP026983:482466-482789 [Pectobacterium parmentieri]
MMYADAIKAANNLTSIVPLLGGSTSCKDYEDAPEFVAFNERIKALPAGIALLRILMDQHGLTQSDFEAEIGKKSLVSRIL
NGERTLTVDHMSALAKRFDIPVSAFVD

Download         Length: 324 bp

>AT96970 NZ_CP026983:482466-482789 [Pectobacterium parmentieri]
ATGATGTACGCAGACGCAATCAAGGCCGCTAACAATCTGACGAGTATCGTACCGCTCCTCGGAGGTAGCACCTCTTGTAA
AGATTATGAGGATGCGCCAGAGTTTGTAGCTTTCAACGAGCGTATTAAAGCGCTCCCTGCTGGTATCGCTTTGCTGCGCA
TACTTATGGATCAGCATGGGCTAACGCAAAGTGACTTTGAAGCTGAGATCGGTAAAAAATCTCTGGTATCCCGAATTCTA
AATGGTGAGCGTACACTAACGGTTGATCACATGAGCGCACTTGCTAAACGATTTGATATTCCCGTGAGTGCTTTTGTTGA
TTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A8B3FNM7


Antitoxin

Source ID Structure

References