Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 614618..615120 Replicon chromosome
Accession NZ_CP026981
Organism Pectobacterium parmentieri strain IFB5485

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8B3FFY4
Locus tag C5E21_RS02970 Protein ID WP_025919527.1
Coordinates 614618..614872 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A8B3FIJ8
Locus tag C5E21_RS02975 Protein ID WP_033070807.1
Coordinates 614869..615120 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5E21_RS02950 609724..610986 - 1263 WP_012822274.1 L-rhamnose isomerase -
C5E21_RS02955 610983..612473 - 1491 WP_012822275.1 rhamnulokinase -
C5E21_RS02960 612842..613681 + 840 WP_005971146.1 HTH-type transcriptional activator RhaS -
C5E21_RS02965 613706..614560 + 855 WP_012822276.1 helix-turn-helix domain-containing protein -
C5E21_RS02970 614618..614872 - 255 WP_025919527.1 Txe/YoeB family addiction module toxin Toxin
C5E21_RS02975 614869..615120 - 252 WP_033070807.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C5E21_RS02980 615195..616883 - 1689 WP_025919529.1 ABC transporter ATP-binding protein -
C5E21_RS02985 616880..617746 - 867 WP_012822280.1 ABC transporter permease -
C5E21_RS02990 617739..618698 - 960 WP_012822281.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtB / hcp 531251..674021 142770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10135.66 Da        Isoelectric Point: 8.0367

>T96955 WP_025919527.1 NZ_CP026981:c614872-614618 [Pectobacterium parmentieri]
VKPIWSEAAWEDYLYWQDIDNRIVKKINELIKEIRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITDDAMMIAAC
RYHY

Download         Length: 255 bp

>T96955 NZ_CP026981:c614872-614618 [Pectobacterium parmentieri]
GTGAAGCCAATCTGGTCAGAAGCAGCATGGGAAGACTACCTGTACTGGCAGGATATCGATAATCGGATAGTCAAAAAAAT
CAATGAATTAATAAAAGAAATTCGCAGAACGCCTTTTGAGGGAAAAGGAAAACCAGAGCCGCTTAAACATAATCTTGCTG
GCTTCTGGTCACGCCGTATCACCGAAGAACATCGTCTGGTCTATGCCATCACCGATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9351.64 Da        Isoelectric Point: 4.6119

>AT96955 WP_033070807.1 NZ_CP026981:c615120-614869 [Pectobacterium parmentieri]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNAIESLKAGNGEERD
IIE

Download         Length: 252 bp

>AT96955 NZ_CP026981:c615120-614869 [Pectobacterium parmentieri]
ATGCGTACAATTAGCTACAGCGAAGCCCGCCAAAACCTATCAGCAACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACCCGACAGAATGGCGAAGCCTGTGTGCTGATGTCTCTGGAAGAGTATAACTCTCTAGAAGAAACCGCGTATT
TACTGCGTTCTCCCGCCAATGCCAAAAGACTGATGAATGCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3FFY4

Antitoxin

Source ID Structure
AlphaFold DB A0A8B3FIJ8

References