Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 460413..461131 | Replicon | chromosome |
Accession | NZ_CP026977 | ||
Organism | Pectobacterium parmentieri strain IFB5408 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A8B3FNM7 |
Locus tag | C5E17_RS02220 | Protein ID | WP_033070820.1 |
Coordinates | 460413..460718 (+) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A8B3FM67 |
Locus tag | C5E17_RS02225 | Protein ID | WP_033070769.1 |
Coordinates | 460715..461131 (+) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C5E17_RS02190 | 455768..456502 | + | 735 | WP_012822189.1 | type I-E CRISPR-associated protein Cas5/CasD | - |
C5E17_RS02195 | 456502..457149 | + | 648 | WP_012822190.1 | type I-E CRISPR-associated protein Cas6/Cse3/CasE | - |
C5E17_RS02200 | 457177..458094 | + | 918 | WP_012822191.1 | type I-E CRISPR-associated endonuclease Cas1 | - |
C5E17_RS02205 | 458095..458388 | + | 294 | WP_005973730.1 | type I-E CRISPR-associated endoribonuclease Cas2 | - |
C5E17_RS02210 | 459556..459927 | - | 372 | WP_012822192.1 | helix-turn-helix domain-containing protein | - |
C5E17_RS02215 | 460001..460261 | - | 261 | WP_012822193.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
C5E17_RS02220 | 460413..460718 | + | 306 | WP_033070820.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
C5E17_RS02225 | 460715..461131 | + | 417 | WP_033070769.1 | helix-turn-helix domain-containing protein | Antitoxin |
C5E17_RS02230 | 462290..462748 | + | 459 | WP_012822197.1 | hypothetical protein | - |
C5E17_RS02235 | 462829..464181 | - | 1353 | WP_033070770.1 | aspartate aminotransferase family protein | - |
C5E17_RS02240 | 464212..465483 | - | 1272 | WP_033070821.1 | MFS transporter | - |
C5E17_RS02245 | 465638..466084 | + | 447 | WP_012822200.1 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 12010.78 Da Isoelectric Point: 10.0386
>T96929 WP_033070820.1 NZ_CP026977:460413-460718 [Pectobacterium parmentieri]
VFSRAPFDTAIAQFPNQAAALADLYRTIKREIYATPDDMKKRFPSLDRMKYREKWWVIDIGGGHLRVMFFADFERGKIFI
KHITSHAEYGSLTEYYRRNKE
VFSRAPFDTAIAQFPNQAAALADLYRTIKREIYATPDDMKKRFPSLDRMKYREKWWVIDIGGGHLRVMFFADFERGKIFI
KHITSHAEYGSLTEYYRRNKE
Download Length: 306 bp
>T96929 NZ_CP026977:460413-460718 [Pectobacterium parmentieri]
GTGTTCTCCCGGGCACCTTTTGACACTGCAATCGCCCAATTCCCTAATCAGGCGGCAGCACTGGCTGACCTATACCGGAC
GATAAAGCGTGAAATATATGCAACGCCGGACGATATGAAAAAACGTTTCCCCAGCTTAGACAGGATGAAGTACAGGGAAA
AGTGGTGGGTTATTGATATTGGTGGTGGGCATCTTCGGGTGATGTTTTTCGCTGATTTTGAGCGAGGGAAAATTTTTATC
AAACACATCACATCCCATGCAGAGTACGGCAGTCTGACAGAATATTACCGGAGGAATAAAGAATGA
GTGTTCTCCCGGGCACCTTTTGACACTGCAATCGCCCAATTCCCTAATCAGGCGGCAGCACTGGCTGACCTATACCGGAC
GATAAAGCGTGAAATATATGCAACGCCGGACGATATGAAAAAACGTTTCCCCAGCTTAGACAGGATGAAGTACAGGGAAA
AGTGGTGGGTTATTGATATTGGTGGTGGGCATCTTCGGGTGATGTTTTTCGCTGATTTTGAGCGAGGGAAAATTTTTATC
AAACACATCACATCCCATGCAGAGTACGGCAGTCTGACAGAATATTACCGGAGGAATAAAGAATGA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15233.53 Da Isoelectric Point: 4.3708
>AT96929 WP_033070769.1 NZ_CP026977:460715-461131 [Pectobacterium parmentieri]
MMYADAIKAANNLTSIVPLLGGSTSCKDYEDALKLIEYLLESEPDSPLIDMLTAKIDKYEEDAPEFVAFNERIKALPAGI
ALLRILMDQHGLTQSDFEAEIGKKSLVSRILNGERTLTVDHMSALAKRFDIPVSAFVD
MMYADAIKAANNLTSIVPLLGGSTSCKDYEDALKLIEYLLESEPDSPLIDMLTAKIDKYEEDAPEFVAFNERIKALPAGI
ALLRILMDQHGLTQSDFEAEIGKKSLVSRILNGERTLTVDHMSALAKRFDIPVSAFVD
Download Length: 417 bp
>AT96929 NZ_CP026977:460715-461131 [Pectobacterium parmentieri]
ATGATGTACGCAGACGCAATCAAGGCCGCTAACAATCTGACGAGTATCGTACCGCTCCTCGGAGGTAGCACCTCTTGTAA
AGATTATGAGGATGCGCTGAAACTCATTGAATATTTACTCGAGAGCGAGCCTGATAGCCCGCTAATCGATATGCTGACGG
CTAAAATTGACAAATATGAAGAGGATGCGCCAGAGTTTGTAGCTTTCAACGAGCGTATTAAAGCGCTCCCTGCTGGTATC
GCTTTGCTGCGCATACTTATGGATCAGCATGGGCTAACGCAAAGTGACTTTGAAGCTGAGATCGGTAAAAAATCTCTGGT
ATCCCGAATTCTAAATGGTGAGCGTACACTAACGGTTGATCACATGAGCGCACTTGCTAAACGATTTGATATTCCCGTGA
GTGCTTTTGTTGATTAG
ATGATGTACGCAGACGCAATCAAGGCCGCTAACAATCTGACGAGTATCGTACCGCTCCTCGGAGGTAGCACCTCTTGTAA
AGATTATGAGGATGCGCTGAAACTCATTGAATATTTACTCGAGAGCGAGCCTGATAGCCCGCTAATCGATATGCTGACGG
CTAAAATTGACAAATATGAAGAGGATGCGCCAGAGTTTGTAGCTTTCAACGAGCGTATTAAAGCGCTCCCTGCTGGTATC
GCTTTGCTGCGCATACTTATGGATCAGCATGGGCTAACGCAAAGTGACTTTGAAGCTGAGATCGGTAAAAAATCTCTGGT
ATCCCGAATTCTAAATGGTGAGCGTACACTAACGGTTGATCACATGAGCGCACTTGCTAAACGATTTGATATTCCCGTGA
GTGCTTTTGTTGATTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B3FNM7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B3FM67 |