Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1930484..1930898 Replicon chromosome
Accession NZ_CP026968
Organism Staphylococcus aureus strain FDAARGOS_1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag RK60_RS10145 Protein ID WP_001065046.1
Coordinates 1930647..1930898 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RK60_RS15070 Protein ID WP_000028424.1
Coordinates 1930484..1930657 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK60_RS10090 1926646..1926990 - 345 WP_000402904.1 hypothetical protein -
RK60_RS10095 1927120..1927419 - 300 WP_000988336.1 HNH endonuclease -
RK60_RS10100 1927651..1928067 - 417 WP_000590122.1 hypothetical protein -
RK60_RS10105 1928095..1928295 - 201 WP_000265043.1 DUF1514 family protein -
RK60_RS10110 1928295..1928444 - 150 WP_000595265.1 transcriptional activator RinB -
RK60_RS10115 1928441..1928827 - 387 WP_000592202.1 hypothetical protein -
RK60_RS10120 1928820..1929056 - 237 WP_000608275.1 hypothetical protein -
RK60_RS10125 1929049..1929252 - 204 WP_000141180.1 hypothetical protein -
RK60_RS10130 1929249..1929455 - 207 WP_000195794.1 DUF1381 domain-containing protein -
RK60_RS10135 1929492..1930025 - 534 WP_031928463.1 dUTP diphosphatase -
RK60_RS15065 1930040..1930201 - 162 WP_000889682.1 hypothetical protein -
RK60_RS10140 1930202..1930483 - 282 Protein_1878 hypothetical protein -
RK60_RS15070 1930484..1930657 - 174 WP_000028424.1 hypothetical protein Antitoxin
RK60_RS10145 1930647..1930898 - 252 WP_001065046.1 DUF1024 family protein Toxin
RK60_RS10150 1930891..1931241 - 351 WP_025176279.1 hypothetical protein -
RK60_RS10155 1931250..1931492 - 243 WP_000131381.1 phi PVL orf 51-like protein -
RK60_RS10160 1931496..1931864 - 369 WP_023604910.1 hypothetical protein -
RK60_RS10165 1931877..1932282 - 406 Protein_1884 RusA family crossover junction endodeoxyribonuclease -
RK60_RS10170 1932291..1932509 - 219 WP_000338528.1 hypothetical protein -
RK60_RS10175 1932516..1933385 - 870 WP_025176251.1 DnaD domain protein -
RK60_RS10180 1933415..1933885 - 471 WP_000610649.1 single-stranded DNA-binding protein -
RK60_RS10185 1933886..1934503 - 618 WP_077517322.1 MBL fold metallo-hydrolase -
RK60_RS10190 1934584..1935504 - 921 WP_000138475.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / hlb / groEL 1903100..1955317 52217


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T96904 WP_001065046.1 NZ_CP026968:c1930898-1930647 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T96904 NZ_CP026968:c1930898-1930647 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT96904 WP_000028424.1 NZ_CP026968:c1930657-1930484 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT96904 NZ_CP026968:c1930657-1930484 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References