Detailed information of TA system TA096901

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 1907444..1907751
• Replicon: chromosome
• Accession: NZ_CP026968
• Organism: Staphylococcus aureus strain FDAARGOS_1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: RK60_RS09995
• Protein ID: WP_072357969.1
• Coordinates: 1907575..1907751 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1907444..1907583 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK60_RS09940	1902787..1903047	+	261	WP_001791826.1	hypothetical protein	-
RK60_RS09945	1903100..1903450	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
RK60_RS09950	1904133..1904582	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
RK60_RS09955	1904675..1905009	-	335	Protein_1843	SH3 domain-containing protein	-
RK60_RS09975	1905660..1906151	-	492	WP_000920041.1	staphylokinase	-
RK60_RS09980	1906342..1907097	-	756	WP_000861038.1	CHAP domain-containing protein	-
RK60_RS09985	1907109..1907363	-	255	WP_000611512.1	phage holin	-
RK60_RS09990	1907415..1907522	+	108	WP_031762631.1	hypothetical protein	-
-	1907444..1907583	+	140	NuclAT_0	-	Antitoxin
-	1907444..1907583	+	140	NuclAT_0	-	Antitoxin
-	1907444..1907583	+	140	NuclAT_0	-	Antitoxin
-	1907444..1907583	+	140	NuclAT_0	-	Antitoxin
RK60_RS09995	1907575..1907751	-	177	WP_072357969.1	putative holin-like toxin	Toxin
RK60_RS10000	1907894..1908268	-	375	WP_000340977.1	hypothetical protein	-
RK60_RS10005	1908324..1908611	-	288	WP_001262620.1	hypothetical protein	-
RK60_RS10010	1908657..1908809	-	153	WP_001000058.1	hypothetical protein	-
RK60_RS10015	1908802..1912584	-	3783	WP_016170804.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / hlb / groEL	1903100..1955317	52217

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T96901 WP_072357969.1 NZ_CP026968:c1907751-1907575 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T96901 NZ_CP026968:c1907751-1907575 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT96901 NZ_CP026968:1907444-1907583 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin