Detailed information of TA system TA096894

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 184086..184665
• Replicon: chromosome
• Accession: NZ_CP026968
• Organism: Staphylococcus aureus strain FDAARGOS_1

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: RK60_RS00865
• Protein ID: WP_001025401.1
• Coordinates: 184086..184331 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	184300..184665 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK60_RS00815	179970..180584	+	615	WP_000191459.1	hypothetical protein	-
RK60_RS00820	180581..180727	-	147	WP_001013104.1	hypothetical protein	-
RK60_RS00825	180817..181212	-	396	WP_001558060.1	hypothetical protein	-
RK60_RS00830	181241..181675	-	435	WP_016170817.1	hypothetical protein	-
RK60_RS00835	181693..182154	-	462	WP_000525004.1	hypothetical protein	-
RK60_RS00840	182167..182481	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
RK60_RS00845	182633..182869	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
RK60_RS00850	182883..183659	+	777	WP_025176283.1	Rha family transcriptional regulator	-
RK60_RS00855	183688..183831	+	144	WP_000939498.1	hypothetical protein	-
RK60_RS00860	183821..184030	-	210	WP_000642492.1	hypothetical protein	-
RK60_RS00865	184086..184331	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
RK60_RS00870	184300..184665	-	366	WP_016170627.1	hypothetical protein	Antitoxin
RK60_RS00875	184720..184935	+	216	WP_001097552.1	hypothetical protein	-
RK60_RS00880	184960..185223	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
RK60_RS00885	185237..185398	+	162	WP_047211484.1	DUF1270 family protein	-
RK60_RS00890	185490..185750	+	261	WP_000291090.1	DUF1108 family protein	-
RK60_RS00895	185760..185981	+	222	WP_000815401.1	DUF2483 family protein	-
RK60_RS00900	185974..186597	+	624	WP_000139720.1	DUF1071 domain-containing protein	-
RK60_RS00905	186597..187025	+	429	WP_000934385.1	single-stranded DNA-binding protein	-
RK60_RS00910	187039..187713	+	675	WP_031888948.1	phi PV83 orf 19-like protein	-
RK60_RS00915	187820..188668	-	849	WP_000371251.1	DUF4393 domain-containing protein	-
RK60_RS00920	188732..189445	+	714	WP_000132054.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	178639..222352	43713

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T96894 WP_001025401.1 NZ_CP026968:184086-184331 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T96894 NZ_CP026968:184086-184331 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAGGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT96894 NZ_CP026968:c184665-184300 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin