96879

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1103685..1104202 Replicon chromosome
Accession NZ_CP026964
Organism Staphylococcus aureus strain FDAARGOS_2

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag RK61_RS05470 Protein ID WP_000113262.1
Coordinates 1103936..1104202 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag RK61_RS05465 Protein ID WP_000584499.1
Coordinates 1103685..1103936 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK61_RS05435 1099383..1100102 + 720 WP_000479576.1 amino acid ABC transporter permease -
RK61_RS05440 1100099..1100830 + 732 WP_000615458.1 amino acid ABC transporter ATP-binding protein -
RK61_RS05445 1100927..1102177 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
RK61_RS05450 1102432..1102794 + 363 WP_000819843.1 DUF4467 domain-containing protein -
RK61_RS05455 1102813..1103412 + 600 WP_000162810.1 DsbA family protein -
RK61_RS05460 1103419..1103520 + 102 Protein_1015 hypothetical protein -
RK61_RS05465 1103685..1103936 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RK61_RS05470 1103936..1104202 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
RK61_RS05475 1104496..1106046 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
RK61_RS05480 1106232..1106699 + 468 WP_000153344.1 SRPBCC domain-containing protein -
RK61_RS05485 1106783..1106965 + 183 WP_000230294.1 hypothetical protein -
RK61_RS05490 1107182..1108006 + 825 WP_000572040.1 formate/nitrite transporter family protein -
RK61_RS05495 1108250..1108777 + 528 WP_000973468.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T96879 WP_000113262.1 NZ_CP026964:1103936-1104202 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T96879 NZ_CP026964:1103936-1104202 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT96879 WP_000584499.1 NZ_CP026964:1103685-1103936 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT96879 NZ_CP026964:1103685-1103936 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References