Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2495263..2495780 Replicon chromosome
Accession NZ_CP026962
Organism Staphylococcus aureus strain FDAARGOS_6

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag RK64_RS12835 Protein ID WP_000113262.1
Coordinates 2495263..2495529 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag RK64_RS12840 Protein ID WP_000584499.1
Coordinates 2495529..2495780 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK64_RS12805 2490689..2491225 - 537 WP_000169315.1 GNAT family N-acetyltransferase -
RK64_RS12810 2491458..2492282 - 825 WP_000572040.1 formate/nitrite transporter family protein -
RK64_RS12815 2492499..2492681 - 183 WP_000230294.1 hypothetical protein -
RK64_RS12820 2492765..2493232 - 468 WP_000153344.1 SRPBCC domain-containing protein -
RK64_RS12825 2493418..2494968 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
RK64_RS12830 2495157..2495228 - 72 Protein_2368 hypothetical protein -
RK64_RS12835 2495263..2495529 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
RK64_RS12840 2495529..2495780 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RK64_RS12845 2495945..2496046 - 102 WP_001791744.1 hypothetical protein -
RK64_RS12850 2496053..2496652 - 600 WP_000162813.1 DsbA family protein -
RK64_RS12855 2496671..2497033 - 363 WP_000819843.1 DUF4467 domain-containing protein -
RK64_RS12860 2497288..2498538 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
RK64_RS12865 2498635..2499366 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
RK64_RS12870 2499363..2500082 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T96872 WP_000113262.1 NZ_CP026962:c2495529-2495263 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T96872 NZ_CP026962:c2495529-2495263 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT96872 WP_000584499.1 NZ_CP026962:c2495780-2495529 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT96872 NZ_CP026962:c2495780-2495529 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References