Detailed information of TA system TA096862

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2396045..2396624
• Replicon: chromosome
• Accession: NZ_CP026961
• Organism: Staphylococcus aureus strain FDAARGOS_10

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: Q2FY92
• Locus tag: RK68_RS12915
• Protein ID: WP_001025402.1
• Coordinates: 2396045..2396290 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2396259..2396624 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK68_RS12870	2391114..2392319	-	1206	WP_000264748.1	site-specific integrase	-
RK68_RS12875	2392445..2393059	+	615	WP_000191459.1	hypothetical protein	-
RK68_RS12880	2393056..2393202	-	147	WP_001013104.1	hypothetical protein	-
RK68_RS12885	2393239..2393421	-	183	WP_000705240.1	hypothetical protein	-
RK68_RS12890	2393625..2393966	-	342	WP_000591749.1	hypothetical protein	-
RK68_RS12895	2393972..2394904	-	933	WP_000759682.1	ATP-dependent helicase	-
RK68_RS12900	2394920..2395633	-	714	WP_001031454.1	XRE family transcriptional regulator	-
RK68_RS12905	2395596..2395769	+	174	WP_001801500.1	hypothetical protein	-
RK68_RS12910	2395766..2396029	+	264	WP_000854072.1	helix-turn-helix domain-containing protein	-
RK68_RS12915	2396045..2396290	+	246	WP_001025402.1	DUF2829 domain-containing protein	Toxin
RK68_RS12920	2396259..2396624	-	366	WP_001131647.1	hypothetical protein	Antitoxin
RK68_RS12925	2396679..2396894	+	216	WP_001097552.1	hypothetical protein	-
RK68_RS12930	2396919..2397182	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
RK68_RS12935	2397195..2397356	+	162	WP_001285961.1	DUF1270 domain-containing protein	-
RK68_RS12940	2397435..2397758	+	324	WP_000174996.1	hypothetical protein	-
RK68_RS12945	2397773..2398135	+	363	WP_000279452.1	hypothetical protein	-
RK68_RS12950	2398132..2399298	+	1167	WP_000762540.1	DUF2800 domain-containing protein	-
RK68_RS12955	2399324..2399881	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9434.70 Da
• Isoelectric Point: 5.7783

>T96862 WP_001025402.1 NZ_CP026961:2396045-2396290 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
L

Nucleotide

• Length: 246 bp

>T96862 NZ_CP026961:2396045-2396290 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTATAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT96862 NZ_CP026961:c2396624-2396259 [Staphylococcus aureus]
ATGCCCTTGACATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGATTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTATAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: Q2FY92

Antitoxin