Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 537621..538138 Replicon chromosome
Accession NZ_CP026961
Organism Staphylococcus aureus strain FDAARGOS_10

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag RK68_RS03180 Protein ID WP_000113262.1
Coordinates 537621..537887 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag RK68_RS03185 Protein ID WP_000584499.1
Coordinates 537887..538138 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK68_RS03150 533047..533583 - 537 WP_000169315.1 GNAT family N-acetyltransferase -
RK68_RS03155 533816..534640 - 825 WP_000572040.1 formate/nitrite transporter family protein -
RK68_RS03160 534857..535039 - 183 WP_000230294.1 hypothetical protein -
RK68_RS03165 535123..535590 - 468 WP_000153344.1 SRPBCC domain-containing protein -
RK68_RS03170 535776..537326 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
RK68_RS03175 537515..537586 - 72 Protein_596 hypothetical protein -
RK68_RS03180 537621..537887 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
RK68_RS03185 537887..538138 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RK68_RS03190 538303..538404 - 102 WP_001791744.1 hypothetical protein -
RK68_RS03195 538411..539010 - 600 WP_000162813.1 DsbA family protein -
RK68_RS03200 539029..539391 - 363 WP_000819843.1 DUF4467 domain-containing protein -
RK68_RS03205 539646..540896 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
RK68_RS03210 540993..541724 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
RK68_RS03215 541721..542440 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T96854 WP_000113262.1 NZ_CP026961:c537887-537621 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T96854 NZ_CP026961:c537887-537621 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT96854 WP_000584499.1 NZ_CP026961:c538138-537887 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT96854 NZ_CP026961:c538138-537887 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References