96841

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1817968..1818485 Replicon chromosome
Accession NZ_CP026960
Organism Staphylococcus aureus strain FDAARGOS_15

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag RK73_RS09705 Protein ID WP_000113262.1
Coordinates 1817968..1818234 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag RK73_RS09710 Protein ID WP_000584499.1
Coordinates 1818234..1818485 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK73_RS09675 1813394..1813930 - 537 WP_000169315.1 GNAT family N-acetyltransferase -
RK73_RS09680 1814163..1814987 - 825 WP_000572040.1 formate/nitrite transporter family protein -
RK73_RS09685 1815204..1815386 - 183 WP_000230294.1 hypothetical protein -
RK73_RS09690 1815470..1815937 - 468 WP_000153344.1 SRPBCC domain-containing protein -
RK73_RS09695 1816123..1817673 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
RK73_RS09700 1817862..1817933 - 72 Protein_1802 hypothetical protein -
RK73_RS09705 1817968..1818234 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
RK73_RS09710 1818234..1818485 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RK73_RS09715 1818650..1818751 - 102 WP_001791744.1 hypothetical protein -
RK73_RS09720 1818758..1819357 - 600 WP_000162813.1 DsbA family protein -
RK73_RS09725 1819376..1819738 - 363 WP_000819843.1 DUF4467 domain-containing protein -
RK73_RS09730 1819993..1821243 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
RK73_RS09735 1821340..1822071 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
RK73_RS09740 1822068..1822787 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T96841 WP_000113262.1 NZ_CP026960:c1818234-1817968 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T96841 NZ_CP026960:c1818234-1817968 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT96841 WP_000584499.1 NZ_CP026960:c1818485-1818234 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT96841 NZ_CP026960:c1818485-1818234 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References