Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1545584..1546101 Replicon chromosome
Accession NZ_CP026958
Organism Staphylococcus aureus strain FDAARGOS_40

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag RK98_RS08060 Protein ID WP_000113265.1
Coordinates 1545835..1546101 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag RK98_RS08055 Protein ID WP_000584499.1
Coordinates 1545584..1545835 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK98_RS08025 1541282..1542001 + 720 WP_000479576.1 amino acid ABC transporter permease -
RK98_RS08030 1541998..1542729 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
RK98_RS08035 1542826..1544076 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
RK98_RS08040 1544331..1544693 + 363 WP_000819843.1 DUF4467 domain-containing protein -
RK98_RS08045 1544712..1545311 + 600 WP_000162810.1 DsbA family protein -
RK98_RS08050 1545318..1545419 + 102 Protein_1470 hypothetical protein -
RK98_RS08055 1545584..1545835 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RK98_RS08060 1545835..1546101 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
RK98_RS08065 1546136..1546207 + 72 Protein_1473 hypothetical protein -
RK98_RS08070 1546396..1547943 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
RK98_RS08075 1548129..1548596 + 468 WP_000153347.1 SRPBCC domain-containing protein -
RK98_RS08080 1548680..1548862 + 183 WP_000230292.1 hypothetical protein -
RK98_RS08085 1549079..1549903 + 825 WP_000572038.1 formate/nitrite transporter family protein -
RK98_RS08090 1550137..1550673 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T96825 WP_000113265.1 NZ_CP026958:1545835-1546101 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T96825 NZ_CP026958:1545835-1546101 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT96825 WP_000584499.1 NZ_CP026958:1545584-1545835 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT96825 NZ_CP026958:1545584-1545835 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References