Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1520452..1520636 Replicon chromosome
Accession NZ_CP026958
Organism Staphylococcus aureus strain FDAARGOS_40

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag RK98_RS07900 Protein ID WP_000482652.1
Coordinates 1520452..1520559 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1520576..1520636 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RK98_RS07875 1515814..1516287 + 474 WP_000456486.1 GyrI-like domain-containing protein -
RK98_RS07880 1516410..1517621 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
RK98_RS07885 1517803..1518462 - 660 WP_000831298.1 membrane protein -
RK98_RS07890 1518522..1519664 - 1143 WP_001176863.1 glycerate kinase -
RK98_RS07895 1519932..1520318 + 387 WP_000779360.1 flippase GtxA -
RK98_RS07900 1520452..1520559 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1520576..1520636 - 61 - - Antitoxin
RK98_RS07910 1521262..1523025 + 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
RK98_RS07915 1523050..1524783 + 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
RK98_RS07925 1525014..1525181 + 168 Protein_1448 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T96823 WP_000482652.1 NZ_CP026958:1520452-1520559 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T96823 NZ_CP026958:1520452-1520559 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT96823 NZ_CP026958:c1520636-1520576 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References