Detailed information of TA system TA096818

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 275558..275865
• Replicon: chromosome
• Accession: NZ_CP026958
• Organism: Staphylococcus aureus strain FDAARGOS_40

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: RK98_RS01600
• Protein ID: WP_011447039.1
• Coordinates: 275689..275865 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	275558..275697 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RK98_RS01540	271125..271304	+	180	WP_000669791.1	hypothetical protein	-
RK98_RS01550	271615..271875	+	261	WP_001791826.1	hypothetical protein	-
RK98_RS01555	271927..272277	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
RK98_RS01560	272788..273123	-	336	Protein_261	SH3 domain-containing protein	-
RK98_RS01580	273774..274265	-	492	WP_000920038.1	staphylokinase	-
RK98_RS01585	274480..275211	-	732	WP_000861035.1	CHAP domain-containing protein	-
RK98_RS01590	275223..275477	-	255	WP_000611512.1	phage holin	-
RK98_RS01595	275529..275636	+	108	WP_031762631.1	hypothetical protein	-
-	275558..275697	+	140	NuclAT_0	-	Antitoxin
-	275558..275697	+	140	NuclAT_0	-	Antitoxin
-	275558..275697	+	140	NuclAT_0	-	Antitoxin
-	275558..275697	+	140	NuclAT_0	-	Antitoxin
RK98_RS01600	275689..275865	-	177	WP_011447039.1	putative holin-like toxin	Toxin
RK98_RS01605	275974..276747	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
RK98_RS01610	277120..277494	-	375	WP_000340977.1	hypothetical protein	-
RK98_RS01615	277550..277837	-	288	WP_001262621.1	hypothetical protein	-
RK98_RS01620	277883..278035	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / sell / sec / tsst-1	271927..339549	67622

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T96818 WP_011447039.1 NZ_CP026958:c275865-275689 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T96818 NZ_CP026958:c275865-275689 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT96818 NZ_CP026958:275558-275697 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin