Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 570829..571243 Replicon chromosome
Accession NZ_CP026957
Organism Staphylococcus aureus strain FDAARGOS_43

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag RL01_RS03280 Protein ID WP_001826875.1
Coordinates 570829..571080 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RL01_RS14680 Protein ID WP_000028424.1
Coordinates 571070..571243 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RL01_RS03245 566921..567478 + 558 WP_000645048.1 DUF2815 family protein -
RL01_RS03250 567546..569498 + 1953 WP_001801657.1 DNA polymerase -
RL01_RS03255 569511..569696 + 186 WP_001164629.1 DUF3113 family protein -
RL01_RS03260 569696..570097 + 402 WP_000113974.1 PVL family protein -
RL01_RS03265 570097..570354 + 258 WP_000022728.1 DUF3310 domain-containing protein -
RL01_RS03270 570357..570557 + 201 WP_000235322.1 hypothetical protein -
RL01_RS03275 570572..570814 + 243 WP_000132192.1 hypothetical protein -
RL01_RS03280 570829..571080 + 252 WP_001826875.1 DUF1024 family protein Toxin
RL01_RS14680 571070..571243 + 174 WP_000028424.1 hypothetical protein Antitoxin
RL01_RS03285 571244..571525 + 282 WP_000454993.1 hypothetical protein -
RL01_RS14685 571526..571687 + 162 WP_000889679.1 hypothetical protein -
RL01_RS03290 571702..572235 + 534 WP_001061841.1 dUTPase -
RL01_RS03295 572272..572517 + 246 WP_001282074.1 hypothetical protein -
RL01_RS03300 572514..572702 + 189 WP_000195817.1 DUF1381 domain-containing protein -
RL01_RS03305 572677..572877 + 201 WP_001125015.1 hypothetical protein -
RL01_RS03310 572880..573032 + 153 WP_000237867.1 transcriptional activator RinB -
RL01_RS03315 573100..573300 + 201 WP_000265252.1 DUF1514 family protein -
RL01_RS03325 573588..576035 + 2448 WP_000884870.1 virulence-associated E family protein -
RL01_RS03330 576144..576242 - 99 WP_001801650.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9489.40 Da        Isoelectric Point: 3.9476

>T96803 WP_001826875.1 NZ_CP026957:570829-571080 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAIGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T96803 NZ_CP026957:570829-571080 [Staphylococcus aureus]
ATGAATAATCGTGAACAAATTGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAGAGAAGGTATTGAACTTGATGAAGCAATAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT96803 WP_000028424.1 NZ_CP026957:571070-571243 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT96803 NZ_CP026957:571070-571243 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References