Detailed information of TA system TA096789

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1618623..1619202
• Replicon: chromosome
• Accession: NZ_CP026953
• Organism: Staphylococcus aureus strain FDAARGOS_48

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: RL06_RS08520
• Protein ID: WP_001025401.1
• Coordinates: 1618623..1618868 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1618837..1619202 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RL06_RS08470	1614507..1615121	+	615	WP_000191459.1	hypothetical protein	-
RL06_RS08475	1615118..1615264	-	147	WP_001013104.1	hypothetical protein	-
RL06_RS08480	1615354..1615749	-	396	WP_001558060.1	hypothetical protein	-
RL06_RS08485	1615778..1616212	-	435	WP_016170817.1	hypothetical protein	-
RL06_RS08490	1616230..1616691	-	462	WP_000525004.1	hypothetical protein	-
RL06_RS08495	1616704..1617018	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
RL06_RS08500	1617170..1617406	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
RL06_RS08505	1617420..1618196	+	777	WP_025176283.1	Rha family transcriptional regulator	-
RL06_RS08510	1618225..1618368	+	144	WP_000939498.1	hypothetical protein	-
RL06_RS08515	1618358..1618567	-	210	WP_000642492.1	hypothetical protein	-
RL06_RS08520	1618623..1618868	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
RL06_RS08525	1618837..1619202	-	366	WP_016170627.1	hypothetical protein	Antitoxin
RL06_RS08530	1619257..1619472	+	216	WP_001097552.1	hypothetical protein	-
RL06_RS08535	1619497..1619760	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
RL06_RS08540	1619774..1619935	+	162	WP_047211484.1	DUF1270 family protein	-
RL06_RS08545	1620027..1620287	+	261	WP_000291090.1	DUF1108 family protein	-
RL06_RS08550	1620297..1620518	+	222	WP_000815401.1	DUF2483 family protein	-
RL06_RS08555	1620511..1621134	+	624	WP_000139720.1	DUF1071 domain-containing protein	-
RL06_RS08560	1621134..1621562	+	429	WP_000934385.1	single-stranded DNA-binding protein	-
RL06_RS08565	1621576..1622250	+	675	WP_031888948.1	phi PV83 orf 19-like protein	-
RL06_RS08570	1622357..1623205	-	849	WP_000371251.1	DUF4393 domain-containing protein	-
RL06_RS08575	1623269..1623982	+	714	WP_000132054.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	1603930..1656889	52959

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T96789 WP_001025401.1 NZ_CP026953:1618623-1618868 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T96789 NZ_CP026953:1618623-1618868 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAGGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT96789 NZ_CP026953:c1619202-1618837 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin