Detailed information of TA system TA096785

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 959369..959553
• Replicon: chromosome
• Accession: NZ_CP026953
• Organism: Staphylococcus aureus strain FDAARGOS_48

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: RL06_RS05370
• Protein ID: WP_000482652.1
• Coordinates: 959446..959553 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	959369..959429 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RL06_RS05345	954824..954991	-	168	Protein_975	hypothetical protein	-
RL06_RS05355	955222..956955	-	1734	WP_000486487.1	ABC transporter ATP-binding protein/permease	-
RL06_RS05360	956980..958743	-	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
-	959369..959429	+	61	-	-	Antitoxin
RL06_RS05370	959446..959553	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
RL06_RS05375	959687..960073	-	387	WP_000779360.1	flippase GtxA	-
RL06_RS05380	960341..961483	+	1143	WP_001176863.1	glycerate kinase	-
RL06_RS05385	961543..962202	+	660	WP_000831298.1	membrane protein	-
RL06_RS05390	962384..963595	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
RL06_RS05395	963718..964191	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T96785 WP_000482652.1 NZ_CP026953:c959553-959446 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T96785 NZ_CP026953:c959553-959446 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT96785 NZ_CP026953:959369-959429 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin