Detailed information of TA system TA096784

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 933884..934401
• Replicon: chromosome
• Accession: NZ_CP026953
• Organism: Staphylococcus aureus strain FDAARGOS_48

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: RL06_RS05210
• Protein ID: WP_000113265.1
• Coordinates: 933884..934150 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: RL06_RS05215
• Protein ID: WP_000584499.1
• Coordinates: 934150..934401 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RL06_RS05180	929312..929848	-	537	WP_000169317.1	GNAT family N-acetyltransferase	-
RL06_RS05185	930082..930906	-	825	WP_000572038.1	formate/nitrite transporter family protein	-
RL06_RS05190	931123..931305	-	183	WP_000230292.1	hypothetical protein	-
RL06_RS05195	931389..931856	-	468	WP_000153347.1	SRPBCC domain-containing protein	-
RL06_RS05200	932042..933589	-	1548	WP_000727756.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
RL06_RS05205	933778..933849	-	72	Protein_950	hypothetical protein	-
RL06_RS05210	933884..934150	-	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
RL06_RS05215	934150..934401	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
RL06_RS05220	934566..934667	-	102	Protein_953	hypothetical protein	-
RL06_RS05225	934674..935273	-	600	WP_000162810.1	DsbA family protein	-
RL06_RS05230	935292..935654	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
RL06_RS05235	935909..937159	+	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
RL06_RS05240	937256..937987	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
RL06_RS05245	937984..938703	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T96784 WP_000113265.1 NZ_CP026953:c934150-933884 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T96784 NZ_CP026953:c934150-933884 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT96784 WP_000584499.1 NZ_CP026953:c934401-934150 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT96784 NZ_CP026953:c934401-934150 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Toxin

• PDB: 7BWF

Antitoxin

• AlphaFold DB: T1YB60