Detailed information of TA system TA096779

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 525198..525612
• Replicon: chromosome
• Accession: NZ_CP026953
• Organism: Staphylococcus aureus strain FDAARGOS_48

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: RL06_RS02940
• Protein ID: WP_001065046.1
• Coordinates: 525361..525612 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: RL06_RS15015
• Protein ID: WP_000028424.1
• Coordinates: 525198..525371 (-)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RL06_RS02885	521360..521704	-	345	WP_000402904.1	hypothetical protein	-
RL06_RS02890	521834..522133	-	300	WP_000988336.1	HNH endonuclease	-
RL06_RS02895	522365..522781	-	417	WP_000590122.1	hypothetical protein	-
RL06_RS02900	522809..523009	-	201	WP_000265043.1	DUF1514 family protein	-
RL06_RS02905	523009..523158	-	150	WP_000595265.1	transcriptional activator RinB	-
RL06_RS02910	523155..523541	-	387	WP_000592202.1	hypothetical protein	-
RL06_RS02915	523534..523770	-	237	WP_000608275.1	hypothetical protein	-
RL06_RS02920	523763..523966	-	204	WP_000141180.1	hypothetical protein	-
RL06_RS02925	523963..524169	-	207	WP_000195794.1	DUF1381 domain-containing protein	-
RL06_RS02930	524206..524739	-	534	WP_023604907.1	dUTP diphosphatase	-
RL06_RS15010	524754..524915	-	162	WP_000889682.1	hypothetical protein	-
RL06_RS02935	524916..525197	-	282	Protein_530	hypothetical protein	-
RL06_RS15015	525198..525371	-	174	WP_000028424.1	hypothetical protein	Antitoxin
RL06_RS02940	525361..525612	-	252	WP_001065046.1	DUF1024 family protein	Toxin
RL06_RS02945	525605..525955	-	351	WP_025176279.1	hypothetical protein	-
RL06_RS02950	525964..526206	-	243	WP_023604909.1	phi PVL orf 51-like protein	-
RL06_RS02955	526210..526578	-	369	WP_023604910.1	hypothetical protein	-
RL06_RS02960	526591..526996	-	406	Protein_536	RusA family crossover junction endodeoxyribonuclease	-
RL06_RS02965	527005..527223	-	219	WP_000338528.1	hypothetical protein	-
RL06_RS02970	527230..528099	-	870	WP_025176251.1	DnaD domain protein	-
RL06_RS02975	528129..528599	-	471	WP_000610649.1	single-stranded DNA-binding protein	-
RL06_RS02980	528600..529217	-	618	WP_077517322.1	MBL fold metallo-hydrolase	-
RL06_RS02985	529298..530218	-	921	WP_000138475.1	recombinase RecT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / hlb / groEL	497814..553062	55248

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9377.26 Da
• Isoelectric Point: 3.7128

>T96779 WP_001065046.1 NZ_CP026953:c525612-525361 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T96779 NZ_CP026953:c525612-525361 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT96779 WP_000028424.1 NZ_CP026953:c525371-525198 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT96779 NZ_CP026953:c525371-525198 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA