Detailed information of TA system TA096776

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 502158..502465
• Replicon: chromosome
• Accession: NZ_CP026953
• Organism: Staphylococcus aureus strain FDAARGOS_48

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: RL06_RS02790
• Protein ID: WP_072357969.1
• Coordinates: 502289..502465 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	502158..502297 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RL06_RS02735	497501..497761	+	261	WP_001791826.1	hypothetical protein	-
RL06_RS02740	497814..498164	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
RL06_RS02745	498847..499296	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
RL06_RS02750	499389..499723	-	335	Protein_494	SH3 domain-containing protein	-
RL06_RS02770	500374..500865	-	492	WP_000920041.1	staphylokinase	-
RL06_RS02775	501056..501811	-	756	WP_000861038.1	CHAP domain-containing protein	-
RL06_RS02780	501823..502077	-	255	WP_000611512.1	phage holin	-
RL06_RS02785	502129..502236	+	108	WP_031762631.1	hypothetical protein	-
-	502158..502297	+	140	NuclAT_0	-	Antitoxin
-	502158..502297	+	140	NuclAT_0	-	Antitoxin
-	502158..502297	+	140	NuclAT_0	-	Antitoxin
-	502158..502297	+	140	NuclAT_0	-	Antitoxin
RL06_RS02790	502289..502465	-	177	WP_072357969.1	putative holin-like toxin	Toxin
RL06_RS02795	502608..502982	-	375	WP_000340977.1	hypothetical protein	-
RL06_RS02800	503038..503325	-	288	WP_001262620.1	hypothetical protein	-
RL06_RS02805	503371..503523	-	153	WP_001000058.1	hypothetical protein	-
RL06_RS02810	503516..507298	-	3783	WP_016170804.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / hlb / groEL	497814..553062	55248

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T96776 WP_072357969.1 NZ_CP026953:c502465-502289 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T96776 NZ_CP026953:c502465-502289 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT96776 NZ_CP026953:502158-502297 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin