Detailed information of TA system TA096611

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1529179..1529834
• Replicon: chromosome
• Accession: NZ_CP026918
• Organism: Bordetella pertussis strain J132

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: C5E83_RS07465
• Protein ID: WP_047122780.1
• Coordinates: 1529179..1529430 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: C5E83_RS07470
• Protein ID: WP_003809516.1
• Coordinates: 1529433..1529834 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5E83_RS07440	1524340..1525470	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
C5E83_RS07445	1525705..1526286	+	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
C5E83_RS07450	1526423..1527487	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
C5E83_RS07455	1527572..1528018	-	447	WP_003819827.1	GFA family protein	-
C5E83_RS07460	1528243..1529124	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
C5E83_RS07465	1529179..1529430	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
C5E83_RS07470	1529433..1529834	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
C5E83_RS07475	1529854..1530090	+	237	WP_010930404.1	membrane protein	-
C5E83_RS07480	1530098..1530577	+	480	WP_010930405.1	disulfide bond formation protein B	-
C5E83_RS07485	1530727..1531242	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
C5E83_RS07490	1531245..1532435	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
C5E83_RS07495	1532455..1533492	+	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
C5E83_RS07500	1533629..1534651	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T96611 WP_047122780.1 NZ_CP026918:1529179-1529430 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T96611 NZ_CP026918:1529179-1529430 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT96611 WP_003809516.1 NZ_CP026918:1529433-1529834 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT96611 NZ_CP026918:1529433-1529834 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6